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You are here: Home / Articles / 2014 ACR/ARHP Annual Meeting: Lupus Nephritis

2014 ACR/ARHP Annual Meeting: Lupus Nephritis

February 1, 2015 • By Mary Beth Nierengarten

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Table 3 (above) summarizes the key findings to date of the safety and efficacy of the Rituxilup regimen in the treatment of lupus nephritis.

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Based on these good results, Dr. Lightstone and her colleagues are initiating an investigator-led open-label, multicenter, international, randomized controlled trial evaluating the noninferiority of the Rituxilup regimen (MP + MMF + rituximab) to the combination regimen (MP + MMF + steroids) in inducing renal remission in patients with lupus nephritis.

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Mary Beth Nierengarten is a freelance medical journalist based in St. Paul, Minn.

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Second Chance

If you missed this session, Forefronts in Lupus Nephritis, it’s not too late. Catch it on SessionSelect: http://acr.peachnewmedia.com/store/provider/provider09.php.

References

  1. Dooley MA, Jayne D, Ginzler EM, et al. Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. N Engl J Med. 2011;365(20):1886–1895.
  2. Fischer-Betz R, Chehab G, Sander O, et al. Renal outcome in patients with lupus nephritis using a steroid-free regimen of monthly intravenous cyclophosphamide: A prospective observational study. J Rheumatol. 2012;39(11):2111–2117.
  3. Zeher M, Doria A, Lan J, et al. Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis. Lupus. 2011;20(14):1484–1493.
  4. Ruiz-Irastorza G, Danza A, Perales I, et al. Prednisone in lupus nephritis: How much is enough? Autoimmunity Reviews. 2014;13:206–214.
  5. Condon MB, Ashby D, Pepper RJ, et al. Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis. 2013;72:1280–1286.

 

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Filed Under: Conditions, Meeting Reports, SLE (Lupus) Tagged With: AC&R, Annual Meeting, Association of Rheumatology Professionals (ARP), drug, Lupus nephritis, Nierengarten, therapyIssue: February 2015

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