NEW YORK (Reuters Health)—Although histomorphometry of iliac bone gives precise results, bone turnover markers provide a better reflection of the overall skeleton in untreated postmenopausal osteoporotic women, according to French researchers.
Bone histomorphometry allows study of bone remodeling at the basic structural unit level, Dr. Pascale Chavassieux and colleagues at the University of Lyon note in the Journal of Clinical Endocrinology and Metabolism, online Oct. 27.
However, the most sensitive and widely used markers of formation are serum osteocalcin, the bone isoenzyme of alkaline phosphatase (bone ALP) and the procollagen type 1 N-terminal propeptide (P1NP), they add.
To investigate the correlation between these approaches, the researchers conducted a post-hoc analysis of data from a previously published trial involving 371 women with at least one osteoporotic fracture. The team examined transilliac bone biopsies and blood samples.| | | Next → | Single Page