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Search results for: Janus kinase inhibitors

The Management of Psoriatic Arthritis: A Review

Samantha C. Shapiro, MD  |  November 17, 2024

WASHINGTON, D.C.—As of November 2024, there are 16 biologic disease-modifying anti-rheumatic drugs (bDMARDs) that are FDA approved for the treatment of psoriatic arthritis (PsA). Incredible news, right? But as my fellowship program director used to say, “There’s no free lunch.” This buffet of options is excellent for our patients, but poses challenges to the practicing…

Filed under:ACR ConvergenceConditionsGuidanceMeeting ReportsPsoriatic Arthritis Tagged with:ACR Convergence 2024ACR Convergence 2024 PsA

Lupus Update: Findings from the Latest Phase 3 Clinical Trials

Michele B. Kaufman, PharmD, BCGP  |  October 11, 2024

Two new treatment studies among patients with systemic lupus erythematosus and lupus nephritis had promising results.

Filed under:Biologics/DMARDsConditionsDrug UpdatesSystemic Lupus Erythematosus Tagged with:dapirolizumab pegolEnd-stage renal diseasekidneyLupus nephritisobinutuzumabsystemic lupus erythematosus (SLE)

3 AC&R Study Summaries: Lupus Fog, SSc Variance By Ethnicity & Tuberculosis Screening in New DMARD Users

Arthritis Care & Research  |  August 7, 2024

Lupus Fog? By Laura C. Plantinga, PhD, Patricia P. Katz, PhD, S. Sam Lim, MD, MPH, C. Barrett Bowling, MD, MSPH, & Jinoos Yazdany, MD, MPH Why was this study done? Perceived cognitive impairment (i.e., lupus fog) is common in systemic lupus erythematosus (SLE). However, comprehensive, multidomain assessments of objective cognitive function are rarely performed….

Filed under:Biologics/DMARDsConditionsDrug UpdatesResearch ReviewsResearch RheumSystemic Lupus ErythematosusSystemic Sclerosis Tagged with:Reading RheumSLE Resource CenterTuberculosis

3 AC&R Study Summaries: Prescribing Patterns, PMR & Glucocorticoids, & Infection Screening

Arthritis Care & Research  |  February 9, 2024

A Shift in Prescribing Patterns Safety issues prompt discontinuation of tofacitinib By Stephanie Song, MD, & Joshua F. Baker, MD, MSCE Why was this study done? The ORAL Surveillance study highlighted risks of cardiac events, thromboembolism (VTE) and malignancy associated with use of Janus kinase inhibitors (JAKi). We sought to determine the impact of safety…

Filed under:Biologics/DMARDsConditionsDrug UpdatesOther Rheumatic ConditionsResearch ReviewsResearch RheumRheumatoid Arthritis Tagged with:GlucocorticoidsInfectionJAK inhibitorsPolymyalgia RheumaticaReading Rheumsteroid-sparing therapiesTofacitinib

Clinical Year in Review: 2023

Samantha C. Shapiro, MD  |  December 4, 2023

SAN DIEGO—At ACR Convergence 2023, Philip Seo, MD, MHS, presented an overview of clinical updates in rheumatology from the past year.

Filed under:ACR ConvergenceBiologics/DMARDsConditionsDrug UpdatesMeeting Reports Tagged with:ACR Convergence 2023ankylosing spondylosisPolymyalgia Rheumatica

The Heterogeneity of Psoriatic Arthritis

David S. Pisetsky, MD, PhD  |  November 21, 2023

SAN DIEGO—Differences between psoriatic arthritis and rheumatoid arthritis highlight the need for the development of imaging modalities, laboratory tests and other biomarkers that are explored and validated specifically for PsA to advance the goal of personalized or precision medicine. In this article, expert David S. Pisetsky, MD, PhD, explores the top research in psoriatic arthritis presented at ACR Convergence 2023.

Filed under:ACR ConvergenceConditionsMeeting ReportsPsoriatic Arthritis Tagged with:ACR Convergence 2023ACR Convergence 2023 PsAPsA Resource Center

Late Summer 2023’s Awards, Appointments & Announcements in Rheumatology

Gretchen Henkel  |  September 11, 2023

PANLAR Names Eric L. Matteson, MD, a 2023 Master Throughout his career at the Mayo Clinic, Rochester, Minn., Eric L. Matteson, MD, currently professor of rheumatology, emeritus, actively engaged with his rheumatology colleagues in Latin America. He participated in conferences, worked on South American publications and brought rheumatology fellows to the Mayo Clinic for training….

Filed under:AwardsProfessional Topics Tagged with:Dr. Eric L. MattesonDr. John J. O’SheaMovers & Shakers

Insights into Methotrexate Toxicity in Elderly Patients with Rheumatic Disease

Michele B. Kaufman, PharmD, BCGP  |  December 12, 2022

Data from a small study show that severe methotrexate toxicity in patients who are 70 years of age and older and have rheumatic disease may be associated with poor renal function and the use of diuretic treatments.

Filed under:Drug Updates Tagged with:ACR Convergence 2022MethotrexateRheumatoid Arthritis (RA)toxicity

COVID-19 Vaccine Responses Among the Immunosuppressed

Thomas R. Collins  |  December 12, 2022

PHILADELPHIA—Patients with rheumatic diseases often mount an adequate immune response after receiving COVID-19 vaccinations, but that is not always the case, and certain medications make patients more prone to having an insufficient response, said Judith James, MD, PhD, chair, Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, at an ACR Convergence…

Filed under:ACR ConvergenceConditionsMeeting Reports Tagged with:ACR Convergence 2022COVID-19vaccination

Highlights from the ACR Review Course 2022

Samantha C. Shapiro, MD  |  December 6, 2022

PHILADELPHIA—At ACR Convergence 2022, the much-anticipated ACR Review Course featured talks from eight experts. Topics reflected the heterogeneity of our field and included Sjögren’s disease, spondyloarthritis (SpA), osteoarthritis (OA), paraneoplastic rheumatic syndromes, metabolic bone disease, statin myopathy, Raynaud’s phenomenon and autoinflammatory syndrome. Here, I share highlights from this comprehensive, six-hour session. Sjögren’s Disease Sara S….

Filed under:ACR ConvergenceConditionsMeeting ReportsOsteoarthritis and Bone DisordersOther Rheumatic ConditionsSjögren’s Disease Tagged with:ACR Convergence 2022ACR Convergence 2022 – ASautoinflammatory diseasemetabolic bone diseaseosteoarthritis (OA)paraneoplastic rheumatic syndromesRaynaud’s phenomenonSjogren'sspondyloarthritis (SpA)statin myopathy

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