Threshold for Kidney Biopsy in Lupus Nephritis From the College | January 6, 2026 In a recent review of research abstracts presented at ACR Convergence 2025, Graciela S. Alarcón, MD, MPH, MACR, discusses studies on how often patients with lupus nephritis should be tested for proteinuria. Read Dr. Alarcón's insights, and then take the quiz below. The 2024 ACR Guideline for the Screening, Treatment, and Management of Patients with Lupus Nephritis established a urine-protein-creatinine ratio (UPCR) of ≥0.5 as the threshold to perform a kidney biopsy and initiate treatment. Research presented at ACR Convergence 2025 suggests that to ensure prompt diagnosis and treatment of lupus nephritis: A. The threshold is appropriate as is. B. The threshold should be raised. C. The threshold should be lowered. None Time's up
