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Gout FocusRheum

Gout is a common form of inflammatory arthritis, affecting ~9.2 million adults (3.9%) in the U.S. The good news: The etiology of gout is well understood, and effective, inexpensive medications exist to treat it. However, gaps in quality of care persist. Below, explore selected content from The Rheumatologist’s collection of research reviews, case reports and clinical articles on advances in the diagnosis and management of gout. Also, gout expert Lisa Stamp, MBChB, FRACP, PhD, sorted through the research abstracts on gout accepted for presentation at ACR Convergence 2024 to bring you the most important concepts and findings.

FEATURED ARTICLE: Allopurinol and Chronic Kidney Disease

ACR Convergence 2024

Sunrise, Sunset: A Look Back on the Year in Rheumatology

December 4, 2024

At the ACR Convergence 2024 Year in Review lecture, experts discussed advancements in disease understanding and treatments, as well as in basic science.

Top Research in Gout from ACR Convergence 2024 at a Glance

November 23, 2024

Dr. Lisa Stamp helps filter the noise to get to the key insights from the research abstracts on gout presented at ACR Convergence 2024.

Better Education on Gout

November 22, 2024

Experts addressed how education and follow-up for patients with gout can improve disease management and highlighted the need for a better construction of gout remission.

Lubricin/CD44/PP2A Pathway Offers New Therapeutic Targets for Patients with Gout

November 22, 2024

Dr. Khaled Elsaid discussed synovial macrophages/monocytes and monosodium urate crystal interactions at a session during ACR Convergence, exploring potential new gout pharmacology targets via the lubricin/CD44/protein phosphatase 2A (PP2A) pathway.

Progress in Gout Education & Remission

September 27, 2024

An ACR Convergence 2024 session will discuss strategies to educate patients about their disease and review the progress toward the concept of remission in gout to better guide physicians.

Novel Mechanisms of Gout Explored

September 27, 2024

In a session at ACR Convergence 2024, expert panelists with go into depth concerning molecular mechanisms that contribute to gout pathogenesis.

Your Gout Guide for ACR Convergence 2024: Dr. Lisa Stamp

September 25, 2024

Lisa Stamp, MBChB, PhD, is here to help the busy clinician by curating a collection of the most significant and notable abstracts in gout research to be presented at ACR Convergence 2024.

Research, Case Reports & More

Urate-Lowering Therapy in the Treatment of Patients with Chronic Kidney Disease

December 2, 2024

In a new-patient consultation for joint pain, you see a 75-year-old man with a history of dementia, stage 3a chronic kidney disease (CKD) and nephrolithiasis. He has a uric acid level of 7.5 mg/dL. His medication list includes 300 mg daily allopurinol. What is NOT an indication for allopurinol? CKD-FIX Elevated serum urate levels are…

3 AC&R Study Summaries: Frailty & Prefrailty in RA, Premature Mortality in Gout & Using Recruitment & Multidisciplinary Care Incentives to Improve Access

May 5, 2024

Frailty & Prefrailty in Patients with RA TNF-α inhibitors associated with higher infection risk By Namrata Singh, MD, MSCI, Katherine D. Wysham, MD, James S. Andrews, MD, & Una E. Makris, MD Why was this study done? Frailty and prefrailty are more common and occur at a younger age in patients with rheumatoid arthritis (RA)…

Gout & Its Comorbidities

January 22, 2024

At ACR Convergence 2023, experts addressed important topics in gout research, including treating and preventing gout flares, lowering urate levels and managing comorbidities, as well as racial inequities in gout treatment, disease burden and outcomes.

Old Disease, New Tricks: A Novel Approach to Understanding Gout

December 7, 2023

SAN DIEGO—Gout has sometimes been called the disease of kings, not only because of the fact that purine-rich foods were long affordable only to wealthier individuals, but also because the disease has been around since the monarchies that existed centuries ago. However, with groundbreaking research leading to a better understanding of gout, we can now…

How to Reduce Gout Flares

November 12, 2023

SAN DIEGO—If patients with gout keep their serum urate (SU) levels very low with urate-lowering therapy (ULT), they have fewer flares, according to a research abstract presented at ACR Convergence 2023.

FDA Approves Canakinumab to Treat Gout Flares

November 3, 2023

Canakinumab has received FDA approval for the treatment of patients with acute gout flares.

Pegloticase Plus Methotrexate Effective for Uncontrolled Gout

August 8, 2023

The 12-month results of the MIRROR study show pegloticase co-administered with methotrexate is beneficial for patients with uncontrolled gout.

Treat to Target Lowers the Risk of Fracture in Patients with Gout

July 26, 2023

Using data from the U.K.’s Health Improvement Network, a primary care database, Wei et al. examined whether urate-lowering therapy (ULT) in a treat-to-target approach for patients with gout reduces the risk of fracture.

Tigulixostat Promising for Patients with Gout & Hyperuricemia

June 28, 2023

In a dose-finding, clinical trial, Terkeltaub et al. examined the safety and efficacy of tigulixostat, a nonpurine xanthine oxidase inhibitor, for lowering the serum urate levels of patients with gout and hyperuricemia.

3 AC&R Study Summaries: Treat to Target in Gout, Response to Biologics in Patients with JIA, & Rehabilitation Dose in Adults with RA

February 14, 2023

Treat to Target in Gout Monitoring & achievement of target serum urate levels By Jing Li & Gabriela Schmajuk, MD, MS Why was this study done? The ACR’s 2020 guideline for the management of gout recommends using a treat-to-target (T2T) approach to lower serum urate (SU). Using the ACR’s RISE registry, we examined the use…

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