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2015 ACR/ARHP Annual Meeting: Immune Mediators Can Impact Inflammatory Response

  |  Issue: March 2016  |  

PGE2 and eicosanoids are a previously unrecognized resident macrophage-specific source of inflammasome activation. When this eicosanoid response is dysregulated, it has severe consequences, and it’s a likely factor in innate immunity-driven diseases, Dr. Gronert said.

Susan Bernstein is a freelance medical journalist based in Atlanta.

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References

  1. Proudman SM, James MJ, Spargo LD, et al. Fish oil in recent onset rheumatoid arthritis: A randomised, double-blind, controlled trial within algorithm-based drug use. Ann Rheum Dis. 2015 Jan;74(1):89–95. doi: 10.1136/annrheumdis-2013-204145. Epub 2013 Sep 30.
  2. Bjerregaard P, Young TK, Hegele RA. Low evidence of cardiovascular disease among the Inuit—What is the evidence? Atherosclerosis. 2003 Feb;166(2):351–357.
  3. Newson J, Stables M, Karra E, et al. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Blood. 11 Sep 2014;124(11):1748–1764. doi: 10.1182/blood-2014-03-562710. Epub 2014 Jul 8.
  4. Von Moltke J, Trinidad NJ, Moayeri M, et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature. 2012 Oct 4;490(7418):107–111. doi: 10.1038/nature11351. Epub 2012 Aug 19.
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