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COVID-19 Vaccine Efficacy & Safety Discussed at Town Hall

Ruth Jessen Hickman, MD  |  Issue: September 2021  |  August 20, 2021

  1. Deepak P, Kim W, Paley MA, et al. Glucocorticoids and B cell depleting agents substantially Impair immunogenicity of mRNA vaccines to SARS-CoV-2. medRxiv. 2021 Apr 9;2021.04.05.21254656. Preprint.
  2. Braun-Moscovici Y, Kaplan M, Braun M, et al. Disease activity and humoral response in patients with inflammatory rheumatic diseases after two doses of the Pfizer mRNA vaccine against SARS-CoV-2. Ann Rheum Dis. 2021 Jun 18:annrheumdis-2021-220503.
  3. Connolly CM, Boyarsky BJ, Ruddy JA, et al. Absence of humoral response after two-dose SARS-CoV-2 messenger RNA vaccination in patients with rheumatic and musculoskeletal diseases: A case series. Ann Intern Med. 2021 May 25:M21–1451.
  4. Furer V, Eviatar T, Zisman D, et al. Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: A multicentre study. Ann Rheum Dis. 2021 Jun 14:annrheumdis-2021-220647.
  5. Geisen UM, Berner DK, Tran F, et al. Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort. Ann Rheum Dis. 2021 Mar 24:annrheumdis-2021-220272.
  6. Haberman RH, Herati R, Simon D, et al. Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease. Ann Rheum Dis. 2021 May 25:annrheumdis-2021-220597.
  7. Mahil SK, Bechman K, Raharja A, et al. The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: A cohort study. Lancet Rheumatol. 2021 Jul 8.
  8. Ruddy JA, Connolly CM, Boyarsky BJ, et al. High antibody response to two-dose SARS-CoV-2 messenger RNA vaccination in patients with rheumatic and musculoskeletal diseases. Ann Rheum Dis. 2021 May 24:annrheumdis-2021-220656.
  9. Simon D, Tascilar K, Fagni F, et al. SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases. Ann Rheum Dis. 2021 May 6:annrheumdis-2021-220461.
  10. Bonelli MM, Mrak D, Perkmann T, et al. SARS-CoV-2 vaccination in rituximab-treated patients: evidence for impaired humoral but inducible cellular immune response. Ann Rheum Dis. 2021 May 6:annrheumdis-2021-220408.
  11. Mrak D, Tobudic S, Koblischke M, et al. SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity. Ann Rheum Dis. 2021 July 20: 10.1136/annrheumdis-2021-220781.
  12. Stefanski A, Rincon-Arevalo H, Schrezenmeier E, et al. B cell numbers predict humoral and cellular response upon SARS-CoV-2 vaccination among patients treated with rituximab. medRxiv. Preprint.
  13. Barbhaiya M, Levine JM, Bykerk VP, Jannat-Khah D, Mandl LA. Systemic rheumatic disease flares after SARS-CoV-2 vaccination among rheumatology outpatients in New York City. Ann Rheum Dis. 2021 Jun 22:annrheumdis-2021-220732.
  14. Machado PM, Lawson-Tovey S, Hyrich K. COVID-19 vaccine safety in patients with rheumatic and musculoskeletal disease [abstract, LB0002]. Ann Rheum Dis. 2021;80(suppl 1):199.
  15. Felten R, Kawka L, Dubois M, et al. Tolerance of COVID-19 vaccination in patients with systemic lupus erythematosus: The international VACOLUP study. Lancet Rheumatol. 2021 Jul 21.
  16. FDA expands authorized use of REGEN-COV (casirivimab and imdevimab). Regeneron news release. 2021 Jul 30.

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Filed under:American College of Rheumatology Tagged with:COVID-19immunosuppressionvaccination

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