Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

  • Conditions
    • Axial Spondyloarthritis
    • Gout and Crystalline Arthritis
    • Myositis
    • Osteoarthritis and Bone Disorders
    • Pain Syndromes
    • Pediatric Conditions
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Sjögren’s Disease
    • Systemic Lupus Erythematosus
    • Systemic Sclerosis
    • Vasculitis
    • Other Rheumatic Conditions
  • FocusRheum
    • ANCA-Associated Vasculitis
    • Axial Spondyloarthritis
    • Gout
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Systemic Lupus Erythematosus
  • Guidance
    • Clinical Criteria/Guidelines
    • Ethics
    • Legal Updates
    • Legislation & Advocacy
    • Meeting Reports
      • ACR Convergence
      • Other ACR meetings
      • EULAR/Other
    • Research Rheum
  • Drug Updates
    • Analgesics
    • Biologics/DMARDs
  • Practice Support
    • Billing/Coding
    • EMRs
    • Facility
    • Insurance
    • QA/QI
    • Technology
    • Workforce
  • Opinion
    • Patient Perspective
    • Profiles
    • Rheuminations
      • Video
    • Speak Out Rheum
  • Career
    • ACR ExamRheum
    • Awards
    • Career Development
  • ACR
    • ACR Home
    • ACR Convergence
    • ACR Guidelines
    • Journals
      • ACR Open Rheumatology
      • Arthritis & Rheumatology
      • Arthritis Care & Research
    • From the College
    • Events/CME
    • President’s Perspective
  • Search

Fellow’s Forum Case Report: Waldenström Macroglobulinemia

Caitlin Kesari, MD, & Avis E. Ware, MD  |  Issue: November 2016  |  November 16, 2016

A 73-year-old white male presented with a one-day history of a cold, painful, right foot. The foot had a blue discoloration to it, particularly the toes. The emergency physician suspected an atheroembolic cause, given this patient’s age and history of coronary artery disease. However, the patient also reported a one-year history of painful pallor in his digits; therefore, further rheumatologic workup for presumed Raynaud’s phenomenon was requested.

History & Labs

The patient’s necrotic digits on his right hand had to be amputated.

The patient’s necrotic digits on his right hand had to be amputated.

The patient reported that nine months prior to the onset of his current symptoms, he was admitted to this same hospital with similar complaints, namely a cold and painful right foot. In fact, he had been admitted multiple times over the preceding two years for painful, blue fingers and toes, thought to be secondary to microembolic disease with an unknown source.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

Each time he presented with these symptoms, he was placed on a heparin drip, and his symptoms spontaneously resolved. Nine months prior, he had been placed on a heparin drip when he presented with a cold and painful right foot. Despite this treatment, on hospital day 3, he suddenly developed cyanosis with necrosis of the third to fifth digits of the right hand, distal to the PIP joints. Thromboembolic disease was suspected, and the patient was found to have a patent foramen ovale that was subsequently closed. A thrombus or vegetation was found on an atrial pacer lead as well.

He was started on warfarin. The necrotic digits of his right hand required surgical amputation, but the right foot symptoms spontaneously improved, and he was discharged home without further sequela.

The patient’s first to fourth digits on his right foot had a bluish discoloration, as did his forefoot.

The patient’s first to fourth digits on his right foot had a bluish discoloration, as did his forefoot.

The patient has a remote history of tobacco use (quit 25 years prior to presentation). He notes that during the past one year, several of his fingers would turn white and were painful, especially when exposed to the cold. He was exposed to extremes of hot and cold weather frequently during his 32 years of service in the army and never noticed his hands becoming painful nor turning white, blue or red. He reports that he has had an unintentional 40 lb. weight loss in the past year. He bruises easily, but attributes this to the warfarin prescribed since his admission nine months earlier for presumed microembolic disease.

Page: 1 2 3 | Single Page
Share: 

Filed under:Conditions Tagged with:case reportClinicalDiagnosisFellowsFellows Forumlymphoplasmacytic lymphomaManagementpatient carepresentationrheumatologysymptomtherapyTreatmenttype I cryoglobulinemiaWaldenström Macroglobulinemia

Related Articles
    Oksana Shufrych TKTK / Shutterstock.com

    Heated Gloves May Improve Hand Function in Diffuse Systemic Sclerosis

    October 16, 2017

    Systemic sclerosis (SSc), a subtype of scleroderma, is a rare, complex autoimmune disease characterized by widespread vasculopathy of the small arteries and fibroblast dysfunction.1,2 It has been described as a fibrosing micro­vascular disease, because vascular injury precedes and leads to tissue fibrosis.3 The resulting Raynaud’s phenomenon, pain, skin thickening and tightening, and multi-organ involvement have…

    Foot Pain a Burden for Rheumatology Patients

    January 13, 2012

    Researchers say it may even correlate with back, hip, and knee pain

    Changing Our Thinking on Osteoarthritis

    March 1, 2010

    It’s time we changed our thinking on osteoarthritis

    Standing on a Hidden Burden: The Oft-Overlooked Problem of Foot and Ankle Osteoarthritis

    Standing on a Hidden Burden: The Oft-Overlooked Problem of Foot and Ankle Osteoarthritis

    November 14, 2021

    The high prevalence and significant burden of osteoarthritis (OA) are well known. But it’s becoming apparent that OA research efforts don’t necessarily match disease prevalence or disability. The International Foot and Ankle Osteoarthritis Consortium (IFOAC) is an international organization of volunteers that seeks to highlight a major and often overlooked problem in OA research—foot and…

  • About Us
  • Meet the Editors
  • Issue Archives
  • Contribute
  • Advertise
  • Contact Us
  • Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 1931-3268 (print). ISSN 1931-3209 (online).
  • DEI Statement
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences