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Shortcomings and Promises of Genome-wide Association Studies
The outcomes of genome-wide association studies (GWAS) have not been what scientists expected, but researchers are developing new approaches to use revelatory GWAS information to identify genetic causal variants, predictors of treatment response, and future opportunities for genetic insight.
Translating Genetic Discoveries into Rheumatic Therapies
SAN DIEGO—Will rheumatologists soon be able to use data from genetics and genome-wide association studies to more accurately predict disease and develop new therapies for rheumatic diseases? At a Nov. 5 session at the 2017 ACR/ARHP Annual Meeting, experts shared their views on how to glean this useful knowledge from genomics studies. The cost to develop…
A 52-Year-Old Lupus Paper Remains Important Today
Over 50 years ago, an article appeared in The New England Journal of Medicine: “Immunologic Factors and Clinical Activity in Systemic Lupus Erythematosus.”1 Written by a young postdoctoral fellow, Peter H. Schur, MD, and colleagues, the article synthesized important work in the field at the time. What follows is a discussion of the historical context…
Large Genome Study Identifies Genetic Risk Factors for Gout
Researchers have identified 28 genome-wide significant urate concentration–associated loci, underscoring the importance of metabolic control in urate production.