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Heart Health: The Immunobiology of Cardiovascular Inflammation

Jason Liebowitz, MD, FACR  |  July 12, 2023

In Sum

The session provided insight into the inflammatory components of the cardiovascular system. Much remains to be discovered on this topic, which clearly has significant implications for older adults and children with inflammatory rheumatic conditions who may be at risk of developing cardiovascular complications of their disease. 


Jason Liebowitz, MD, completed his fellowship in rheumatology at Johns Hopkins University, Baltimore, where he also earned his medical degree. He is an assistant professor of medicine in the Division of Rheumatology at Columbia University Vagelos College of Physicians and Surgeons.

References

  1. Ridker PM, Everett BM, Thuren T, et al. Anti-inflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017 Sep;377(12):1119–1131.
  2. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res. 2012 Jan;110(1):159–173.
  3. Watkins MW, LeWinter MM. Physiologic role of the normal pericardium. Annu Rev Med. 1993;44:171–180.
  4. Beloucif S, Takata M, Shimada M, et al. Influence of pericardial constraint on atrioventricular interactions. Am J Physiol. 1992 Jul;263(1 Pt 2):H125–H134.
  5. van Wijk B, Gunst QD, Moorman AFM, et al. Cardiac regeneration from activated epicardium. PLoS One. 2012;7(9):e44692.
  6. Horckmans M, Ring L, Duchene J, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2017 Jan;38(3):187–197.
  7. Orenstein JM, Shulman ST, Fox LM, et al. Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. PLoS One. 2012;7(6):e38998
  8. Mayordomo-Colunga J, Vivanco-Allende A, López-Alonso I, et al. SARS-CoV-2 spike protein in intestinal cells of a patient with coronavirus disease 2019 multisystem inflammatory syndrome. J Pediatr. 2022 Apr;243:214–218.e5.
  9. Gorelik M, Fall N, Altaye M, et al. Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis. J Rheumatol. 2013 Jul;40(7):1191–1199.

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Filed under:ConditionsMeeting Reports Tagged with:2023 Pediatric Rheumatology SymposiumcardiovascularheartKawasaki diseaseMIS-CMultisystem Inflammatory Syndrome in Children (MIS-C)Myocardial infarctionPediatric Rheumatology

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