Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

How Energy Shifts Lead to Systemic Illness

Rainer H. Straub, MD  |  Issue: July 2011  |  

Dr. Straub is a professor in the Laboratory of Experimental Rheumatology and Neuroendocrine Immunology in the Department of Internal Medicine I, University Hospital in Regensburg, Germany.

References

  1. Straub RH, Cutolo M, Buttgereit F, Pongratz G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med. 2010;267:543-560.
  2. Blaxter K. Energy metabolism in animals and man. Cambridge: Cambridge University Press; 1989.
  3. Rassow J, Hauser K, Netzker R, Deutzmann R. Biochemistry. Stuttgart, Germany: Georg Thieme; 2008.
  4. Iemitsu M, Itoh M, Fujimoto T, Tashiro M, et al. Whole-body energy mapping under physical exercise using positron emission tomography. Med Sci Sports Exerc. 2000;32:2067-2070.
  5. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev. 1997;77:731-758.
  6. Calder PC. Fuel utilization by cells of the immune system. Proc Nutr Soc. 1995;54:65-82.
  7. Maciver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol. 2008;84:949-957.
  8. Frauwirth KA, Thompson CB. Regulation of T lymphocyte metabolism. J Immunol. 2004;172:4661-4665.
  9. Straub RH, Besedovsky HO. Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. FASEB J. 2003;17:2176-2183.
  10. Ostensen M, Almberg K, Koksvik HS. Sex, reproduction, and gynecological disease in young adults with a history of juvenile chronic arthritis. J Rheumatol. 2000;27:1783-1787.
  11. Silva CA, Deen ME, Febronio MV, et al. Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea. Rheumatol Int. 2010 Mar 21 [Epub ahead of print].
  12. Villiger PM, Caliezi G, Cottin V, Forger F, Senn A, Ostensen M. Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis. Ann Rheum Dis. 2010;69:1842-1844.
  13. Soares PM, Borba EF, Bonfa E, Hallak J, Correa AL, Silva CA. Gonad evaluation in male systemic lupus erythematosus. Arthritis Rheum. 2007;56:2352-2361.
  14. Suehiro RM, Borba EF, Bonfa E, et al. Testicular Sertoli cell function in male systemic lupus erythematosus. Rheumatology (Oxford). 2008;47:1692-1697.
  15. Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398-411.
  16. LaFleur C, Granados J, Vargas-Alarcon G, et al. HLA-DR antigen frequencies in Mexican patients with dengue virus infection: HLA-DR4 as a possible genetic resistance factor for dengue hemorrhagic fever. Hum Immunol. 2002;63:1039-1044.
  17. Straub RH, Del Rey A, Besedovsky HO. Emerging concepts for the pathogenesis of chronic disabling inflammatory diseases: Neuroendocrine-immune interactions and evolutionary biology. In: R Ader, ed. Psychoneuroimmunology. San Diego, Calif.: Elsevier Academic Press; 2007:217-232.
  18. Besedovsky HO, Del Rey A. Immune-neuro-endocrine interactions. Endocr Rev. 1996;17:64-102.
  19. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: When the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46-56.
  20. Roubenoff R, Roubenoff RA, Cannon JG, et al. Rheumatoid cachexia: Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest. 1994;93:2379-2386.
  21. Walsmith J, Roubenoff R. Cachexia in rheumatoid arthritis. Int J Cardiol. 2002;85:89-99.
  22. Hahn BH, Grossman J, Ansell BJ, Skaggs BJ, McMahon M. Altered lipoprotein metabolism in chronic inflammatory states: Proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther. 2008;10:213.
  23. Khovidhunkit W, Kim MS, Memon RA, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res. 2004;45:1169-1196.
  24. Schäffler A, Müller-Ladner U, Schölmerich J, Büchler C. Role of adipose tissue as an inflammatory organ in human diseases. Endocr Rev. 2006;27:449-467.
  25. Cutolo M, Straub RH, Bijlsma JW. Neuroendocrine-immune interactions in synovitis. Nat Clin Pract Rheumatol. 2007;3:627-634.
  26. Straub RH, Lowin T, Klatt S, Wolff C, Rauch L. Increased density of sympathetic nerve fibers in metabolically activated fat tissue surrounding human synovium and mouse lymph nodes in arthritis. Arthritis Rheum. 2011 Jun 23 [Epub ahead of print].
  27. Tsigos C, Papanicolaou DA, Kyrou I, Raptis SA, Chrousos GP. Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J Interferon Cytokine Res. 1999;19:1271-1276.
  28. Rivier C. Role of endotoxin and interleukin-1 in modulating ACTH, LH and sex steroid secretion. Adv Exp Med Biol. 1990;274:295-301.
  29. Dekkers JC, Geenen R, Godaert GL, Bijlsma JW, van Doornen LJ. Elevated sympathetic nervous system activity in patients with recently diagnosed rheumatoid arthritis with active disease. Clin Exp Rheumatol. 2004;22:63-70.
  30. Sloan RP, McCreath H, Tracey KJ, Sidney S, Liu K, Seeman T. RR interval variability is inversely related to inflammatory markers: The CARDIA study. Mol Med. 2007;13:178-184.
  31. Rosas-Ballina M, Tracey KJ. Cholinergic control of inflammation. J Intern Med. 2009;265:663-679.
  32. Hibbert JM, Creary MS, Gee BE, Buchanan ID, Quarshie A, Hsu LL. Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia. J Pediatr Gastroenterol Nutr. 2006; 43:680-687.
  33. Feske S. Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol. 2007;7:690-702.
  34. Takeda S, Karsenty G. Molecular bases of the sympathetic regulation of bone mass. Bone. 2008;42:837-840.
  35. Duncan H. Osteoporosis in rheumatoid arthritis and corticosteroid induced osteoporosis. Orthop Clin North Am. 1972;3:571-583.
  36. Lee NK, Karsenty G. Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab. 2008; 19:161-166.
  37. Straub RH. Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases. Brain Behav Immun. 2011;25:1-5.

Related Articles

    New Tools for Myositis Diagnosis, Classification & Management

    CHICAGO—At Hot Topics in Myositis, a session at the 2018 ACR/ARHP Annual Meeting, three experts discussed new classification criteria for idiopathic inflammatory myopathies (IIM) and offered practical primers on overlap myositis conditions and inclusion body myositis (IBM). New Myositis Classification Criteria After a 10-year development process, the new EULAR/ACR Classification Criteria for Adult and Juvenile…