ACR CONVERGENCE 2020—With an understanding of the key causes that are behind immune abnormalities in systemic lupus erythematosus (SLE), rheumatologists gain insights into this disease. During the ACR Convergence session Immunology Update—The Decade in Review: 10 Steps to SLE, Chandra Mohan, MD, PhD, Hugh Roy and Lillie Cranz Cullen Endowed Professor, University of Houston, provided an overview of common themes underlying SLE.
Factors that he addressed included interferon and other gene signatures, endosomal and cytosolic DNA/RNA sensors, NETosis, pathogenic T cells and B cells, immunogenic forms of chromatin, and the interactive role of the environment in SLE. For the latter, Dr. Mohan reviewed research related to SLE and the gut microbiota, smoking, and Epstein-Barr virus.
Dr. Mohan also provided recent insights into lupus nephritis and neuropsychiatric SLE.
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