Malignancy Risk in ANCA-Associated Vasculitis Is Lower with Rituximab

Dr. Dennis Ang, a rheumatologist at Wake Forest University in Winston-Salem, N.C., who was not involved in the study, tells Reuters Health by email, “Given that the current standard of care of AAV is to use rituximab during the induction treatment phase, clinicians can be reassured that rituximab is not only efficacious (except for the very severe cases, such as patients on respirator), but also safer—at least during the first five-to-six years post-treatment. It would be interesting to see if these safety data would hold true at 10 or 15 years post-treatment.”

Reference

van Daalen EE, Rizzo R, Kronbichler A, et al. Effect of rituximab on malignancy risk in patients with ANCA-associated vasculitis. Ann Rheum Dis. 2016 Nov 29. pii: annrheumdis-2016-209925. doi: 10.1136/annrheumdis-2016-209925. [Epub ahead of print]

SNOWMASS VILLAGE, COLO.—The study of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is ongoing, and research results should help improve treatment for this patient population. Key trials and therapeutic options were discussed at the 2020 ACR Winter Symposium during the session, Update on the Treatment of ANCA-Associated Vasculitis, by Peter A. Merkel, MD, MPH, chief of…

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According to a large cohort study of pediatric patients, rituximab use is on the rise in the treatment of children diagnosed with vasculitis. Treatment with cyclophosphamide remains common, but it’s beginning to wane. Dialysis and mechanical ventilation also remain common, the study indicates. The retrospective study of hospitalized children in the U.S. included the largest…

Severe infections occurred in 25% of patients with anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV) who were treated with rituximab, according to results of an observational study conducted in the United Kingdom (U.K.) and Austria. Trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis, however, reduced the risk of severe infections, the investigators reported in Annals of the Rheumatic Diseases.1 Andreas…

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