Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

  • Conditions
    • Axial Spondyloarthritis
    • Gout and Crystalline Arthritis
    • Myositis
    • Osteoarthritis and Bone Disorders
    • Pain Syndromes
    • Pediatric Conditions
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Sjögren’s Disease
    • Systemic Lupus Erythematosus
    • Systemic Sclerosis
    • Vasculitis
    • Other Rheumatic Conditions
  • FocusRheum
    • ANCA-Associated Vasculitis
    • Axial Spondyloarthritis
    • Gout
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Systemic Lupus Erythematosus
  • Guidance
    • Clinical Criteria/Guidelines
    • Ethics
    • Legal Updates
    • Legislation & Advocacy
    • Meeting Reports
      • ACR Convergence
      • Other ACR meetings
      • EULAR/Other
    • Research Rheum
  • Drug Updates
    • Analgesics
    • Biologics/DMARDs
  • Practice Support
    • Billing/Coding
    • EMRs
    • Facility
    • Insurance
    • QA/QI
    • Technology
    • Workforce
  • Opinion
    • Patient Perspective
    • Profiles
    • Rheuminations
      • Video
    • Speak Out Rheum
  • Career
    • ACR ExamRheum
    • Awards
    • Career Development
  • ACR
    • ACR Home
    • ACR Convergence
    • ACR Guidelines
    • Journals
      • ACR Open Rheumatology
      • Arthritis & Rheumatology
      • Arthritis Care & Research
    • From the College
    • Events/CME
    • President’s Perspective
  • Search

Nature vs. Nurture & Their Roles in Autoimmunity

Bharat Kumar, MD, MME, FACP, FAAAAI, RhMSUS  |  Issue: May 2025  |  May 12, 2025

The everyday mystery of Bob and John continues to tantalize me. Whenever I can, I share their story with trainees to show the limits of our knowledge. Yet the word mystery makes it out to be something that deserves to be solved, that there is a gnawing void that needs to be filled with information. After so much thought and reflection, I’ve realized this void is inevitable because every time we encroach upon the expanse of unknowability in the world, we become more acutely aware of our ignorance and insignificance. In so doing, a larger and more enigmatic void presents itself. That, fundamentally, is the beauty of the immune system and our world at large.

So I thank Bob and I thank John for entering my life. In coming to clinic with an everyday mystery, they have left me with an everyday opportunity to look at the universe and be infinitely grateful that I get to experience it as a rheumatologist.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

Bharat Kumar, MDBharat Kumar, MD, MME, FACP, FAAAAI, RhMSUS, is the director of the rheumatology fellowship training program at the University of Iowa, Iowa City, and the physician editor of The Rheumatologist. Follow him on X (formerly Twitter) @BharatKumarMD.

 

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

 

References

  1. Tusseau M, Khaldi-Plassart S, Cognard J, et al. Mendelian causes of autoimmunity: the lupus phenotype. J Clin Immunol. 2024 Apr 15;44(4):99.
  2. Biton J, Saidenberg-Kermanac’h N, Decker P, et al. The exposome in rheumatoid arthritis. Joint Bone Spine. 2022 Nov;89(6):105455.
  3. Antonaccio O, Botchkovar EV, Lorine A. Hughes LA. Ecological determinants of situated choice in situational action theory: Does neighborhood matter? J Res Crime Delinq. 2017;54(2):208–243.
  4. Mortezavi M, Martin DA, Schulze-Koops H. After 25 years of drug development, do we know JAK? RMD Open. 2022 Jul;8(2):e002409.

Page: 1 2 3 4 5 | Single Page
Share: 

Filed under:OpinionRheuminations Tagged with:DNAepigeneticsgenetic riskgenetics

Related Articles

    Is B a Key to Autoimmune Therapy?: B Cell–targeted Therapies in Autoimmune Disease

    January 1, 2010

    A perspective on B cell–targeted therapies in autoimmune disease

    Cellular Therapy of Autoimmune Disease

    November 1, 2008

    Is a novel treatment breakthrough on the horizon?

    T Cells in Systemic Lupus Erythematosus

    August 1, 2011

    Progress toward targeted therapy

    Large Vessel Vasculitis

    December 1, 2023

    SAN DIEGO—The large vessel vasculitides, including Takayasu’s arteritis and giant cell arteritis, experienced a surge of interest at ACR Convergence 2023. Here, we highlight important points from 10 of the studies presented at this conference.

  • About Us
  • Meet the Editors
  • Issue Archives
  • Contribute
  • Advertise
  • Contact Us
  • Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 1931-3268 (print). ISSN 1931-3209 (online).
  • DEI Statement
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences