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Risk of Adverse Outcomes Due to COVID-19 May Be Lower with TNF Inhibitor Monotherapy

Katie Robinson  |  Issue: June 2022  |  May 5, 2022

“Of course, we are waiting for larger cohorts. In addition, considering the importance of IL-6 in the COVID-19 cytokine storm, I am looking forward to seeing the impact of the use of IL-6 inhibitors in the progression of COVID-19 in IMIDs,” Dr. Velloso says.


Katie Robinson is a medical writer based in New York.

References

  1. Izadi Z, Brenner EJ, Mahil SK, et al. Association between tumor necrosis factor inhibitors and the risk of hospitalization or death among patients with immune-mediated inflammatory disease and COVID-19. JAMA Netw Open. 2021 Oct 1;4(10):e2129639.
  2. Hyrich KL, Machado PM. Rheumatic disease and COVID-19: Epidemiology and outcomes. Nat Rev Rheumatol. 2021 Feb;17(2):71–72.
  3. Brenner EJ, Ungaro RC, Gearry RB, et al. Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: Results from an international registry. Gastroenterology. 2020 Aug;159(2):481–491.e3.
  4. Gianfrancesco M, Hyrich KL, Al-Adely S, et al. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: Data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis. 2020 Jul;79(7):859–866.
  5. Mahil SK, Dand N, Mason KJ, et al. Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry-based study. J Allergy Clin Immunol. 2021 Jan;147(1):60–71.
  6. Velloso LA. Use of tumor necrosis factor inhibitors during the COVID-19 pandemic—evidence in favor of monotherapy. JAMA Netw Open. 2021 Oct 1;4(10):e2129707.

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Filed under:Conditions Tagged with:COVID-19COVID-19 Global Rheumatology Allianceimmune-mediated inflammatory diseases (IMIDs)monotherapyTNF inhibitors

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