ACR Convergence 2025| Video: Rheum for Everyone, Episode 26—Ableism

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Does High-Intensity Interval Training Lower Inflammatory Disease Activity?

Kurt Ullman  |  November 4, 2025

Encourage maintenance of some general movement through the duration of the flare. Then, as the flare subsides, exercise can ramp back up as tolerated.

Look at HIIT as a medicine, and be specific when prescribing by noting the FITT variables of frequency, intensity, time and type. As treatment continues, evaluate and moderate intensive training for long-term outcomes.

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“One caveat to keep in mind when deciding on HIIT for your patients is that long term benefits are unknown,” said Dr. Huffman. “Short-term benefits show its potential as an initial strategy to improve fitness, immune function and exercise self-efficacy.”


Kurt Ullman is a freelance writer based in Indiana.

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References

  1. Bartlett DB, Willis LH, Slentz CA, et. al. Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: A pilot. Arthritis Res Ther. 2018 June 14;20(1):127.
  2. Andonian BJ, Ross LM, Sudnick AM. Effect of remotely supervised weight loss and exercise training versus lifestyle counseling on cardiovascular risk and clinical outcomes in older adults with rheumatoid arthritis: A randomized controlled trial. ACR Open Rheumatol. 2024 Mar; 6(13):124–136.
  3. Thomsen RS, Nilsen TL, Haugeberg G, et al. Impact of high-intensity interval training on disease activity and disease in patients with psoriatic arthritis: A randomized controlled trial. Arthritis Care Res (Hoboken). 2019 April;71(4)530–537.
  4. Norden KR, Semb AG, Dagfinrud H, et. al. Effect of high-intensity interval training in physiotherapy primary care for patients with inflammatory arthritis: The ExeHeart randomized controlled trial. RMD Open. 2024 Jan 18;10(1);e003440.

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