In a long-term study, secukinumab proved safe and effective for treating ankylosing spondylitis…
Ixekizumab Improves Outcomes of Ankylosing Spondylitis
NEW YORK (Reuters Health)—Ixekizumab improves signs and symptoms in patients with radiographic axial spondyloarthritis (ankylosing spondylitis), according to results from the COAST-W study. “Ankylosing spondylitis is a chronic and debilitating disease, and I have a large number of patients who have failed TNF inhibitors,” says Dr. Atul Deodhar from Oregon Health and Science University, Portland….
Is More Better? Weight Loss Analysis in Older Patients with Knee OA
Obesity is a modifiable risk factor for many patients with knee osteoarthritis (OA), and the National Institutes of Health recommend an initial weight loss goal of 10%. But how does losing more weight affect knee OA patients? In a new study, researchers compared the outcomes of knee OA patients who lost more and less than the recommended 10% of their baseline weight, finding significant improvement in health-related quality of life and reduction in pain for patients who lost twice what’s recommended…
Genetic Discoveries Pave New Pathways to the Origins of Rheumatic Diseases
New research has provided a never-before-seen view of the genetic activity that may be used to map the polygenic nature of common rheumatic diseases. Two recent studies have employed distinct approaches to identify the non-coding gene variants, digging deep into human genetic data to uncover the mechanism of rheumatic diseases…
Mirtazapine Ineffective for Fibromyalgia
Mirtazapine has been prescribed off-label to fibromyalgia patients who have not responded to other treatments. However, a recent systemic review found no difference between mirtazapine and placebo for these patients, and any potential benefits from mirtazapine may not outweigh its potential harm, including drowsiness, weight gain and liver damage…
Gene Therapy for OA
Background & objective: One of the major challenges in the treatment of chronic joint diseases, such as osteoarthritis (OA), is the need to provide sustained bioavailability of a therapeutic agent within the joint. Systemically administered drugs cannot sufficiently reach the synovial space, and intra-articularly injected agents are cleared from the joint fluid rapidly by the…
Sjögren’s Syndrome: Beyond Dryness
CHICAGO—Diagnostic and treatment tips on Sjögren’s syndrome from the experts at the 2018 ACR/ARHP Annual Meeting.
FDA Approves Subcutaneous Tocilizumab for Ages 2–17
The FDA has approved subcutaneous tocilizumab for treating active systemic juvenile idiopathic arthritis in pediatric patients as young as 2 years old…
Central Sensitization to Pain May Not Predict Long-Term Outcomes after Carpal Tunnel Release Surgery
Pain sensitization, such as that experienced by patients with carpal tunnel syndrome (CTS), has been associated with poorer clinical outcomes after surgery. New research has found that, although pain sensitization in CTS patients correlates with preoperative symptom severity, CTS symptoms did not have a persistent effect on functional outcomes after surgery…
Tennis-Wozniacki Reveals Battle with Rheumatoid Arthritis
SINGAPORE (Reuters)—Australian Open champion Caroline Wozniacki has opened up about her battle with rheumatoid arthritis, saying there have been days this year when she found it hard to get out of bed. The Dane, who claimed her maiden Grand Slam title in Melbourne this year, crashed out of the WTA Finals in the group stage…
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