Experts discuss high-intensity interval training as an underused “disease-modifying drug” for inflammatory diseases. Learn how to safely integrate it into patient treatment plans.
Calcium Pyrophosphate Deposition Disease Diagnosis & Treatment Gaps Remain
CPPD diagnosis is difficult & treatments are limited. Experts review radiology challenges, off-label options like colchicine, & emerging biologics.
Research Gets Closer to Development of a Drug to Treat Osteoarthritis
Richard F. Loeser, Jr., MD, MACR, delivering the Oscar Gluck Memorial Lecture at ACR Convergence 2025, discussed research into new treatments for osteoarthritis.
How Lymphatic Drainage Controls Synovial Inflammation
Why do lymphatics fail in inflammatory arthritis? Research from ACR Convergence 2025 points to a network of telocytes & mast cells that control synovial drainage.
Balancing Optimism & Skepticism in CAR T for SLE
At ACR Convergence 2025, Joan T. Merrill, MD, overviewed the current research landscape of chimeric antigen receptor (CAR) T cell therapies for systemic lupus erythematosus (SLE), raising important scientific questions about these emerging treatments.
Incomplete Penetrance in Autoinflammatory Diseases
At this ACR Convergence 2025 session, immunologist Dusan Bogunovic, PhD, discussed his team’s research into how genetic immune diseases manifest with different phenotypes in different people.
Meeting Management Challenges in axSpA
At this ACR Convergence 2025 session, experts discussed emerging concepts with axial spondyloarthritis, including the most effective MRI specifications for diagnosis, challenges with axial juvenile spondyloarthritis & the many mimics of axSpA.
Management of Challenging Cases in Myositis
Immune mediated inflammatory myopathies represent a heterogenous group of diseases with variable degrees of multisystem involvement, including the skin, joints, lungs, and muscles. The ACR Convergence 2025 session, Management of Challenging Cases in Myositis, featured a case-based approach to highlight this complexity, guiding attendees through the nuances of diagnosis and management of antisynthetase syndrome, immune mediated necrotizing myopathy, and dermatomyositis.
The Role of FGL-1 in Sjögren Disease
Fibrinogen-like protein-1 (FGL-1) may play a key role in the onset of autoimmunity by suppressing T cell activation in primary Sjögren disease, according to findings from Otsuka et al. Their study, which examined the influence of interorgan communication on disease pathogenesis in mice models and patients with primary Sjögren disease, may help facilitate novel diagnostic or therapeutic strategies targeting immune checkpoint molecules in autoimmune diseases.
Updates on Fibromyalgia & the Quest to Alleviate Pain
ACR Convergence 2025 speakers reviewed new fibromyalgia insights, from the first new drug approval since 2009 to nociplastic pain concepts & cognitive behavioral therapy.
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