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Systemic Lupus Erythematosus

Can SGLT2 Inhibitors Protect Our SLE Patients?

Samantha C. Shapiro, MD  |  December 4, 2023

SAN DIEGO—At ACR Convergence 2023, Plenary Session 2, April M. Jorge, MD, shared data concerning the potential cardio- and renal-protective benefits of sodium-glucose co-transporter-2 inhibitors in patients with systemic lupus erythematosus and lupus nephritis.

Risks of Severe HCQ Non-Adherence

Arthritis & Rheumatology  |  November 30, 2023

Lower HCQ Serum Levels Associated with SLE Flare, Damage & Mortality Background & Objectives: Nguyen et al. set out to assess the consequences of severe non-adherence to hydroxychloroquine (HCQ) by measuring hydroxychloroquine serum levels, risks of systemic lupus erythematosus (SLE) flares, damage and mortality over five years of follow-up. Methods: The Systemic Lupus Erythematosus International…

Are We Making Progress in Treating Lupus? Clinical Insights from Dr. Michelle Petri

Jason Liebowitz, MD, FACR  |  November 1, 2023

At the 19th Annual Advances in the Diagnosis and Treatment of the Rheumatic Diseases course, Dr. Michelle Petri gave a presentation concerning the overall state of lupus treatment outcomes in the U.S.

Belimumab vs. Oral Immunosuppressants: Infection Risk in Patients with Non-Renal SLE

Arthritis & Rheumatology  |  November 1, 2023

Materne et al. aimed to compare the risk of infection among patients with non-renal SLE using the injectable immunosuppressant belimumab vs. an oral immunosuppressant, azathioprine, mycophenolate or methotrexate.

Break Barriers: Engaging Diverse Participants in Clinical Trials for Patients with Lupus

Jason Liebowitz, MD, FACR  |  September 14, 2023

Misinformation, fear and not having a trusted partner in the medical sector are just a few of the barriers that prevent patients of color from being adequately represented in research and clinical trials for lupus. Experts and patient advocates addressed how to remove these barriers and more during the 2023 ACR Diversification of Clinical Trials Summit.

What Patients with Lupus Want You to Know

Jacqueline Jansz, MD, with Nadera Sweiss, MD  |  August 11, 2023

During a series of interviews with patients who have systemic lupus erythematosus, issues related to medication side effects, supplement use, depression and support groups arose, as well as concerns about race and activities of daily living. The interviews gave me a better understanding of what patients with lupus wish their physicians knew. I am grateful…

Break the Barrier: Understanding & Treating Neuropsychiatric Lupus

Jason Liebowitz, MD, FACR  |  July 10, 2023

Updated research on the complexities of central nervous system (CNS) lupus, as well as its diagnosis and treatment are discussed.

Mixed Results for Rezpegaldesleukin in Patients with Active SLE

Michele B. Kaufman, PharmD, BCGP  |  June 13, 2023

In a clinical trial, patients with active systemic lupus erythematosus (SLE) did not experience a reduction in disease activity with the addition of rezpegaldesleukin to their standard treatments. However, some patient populations did see improvements in their disease activity compared with the placebo-treated group.

New Study Probes Hydroxychloroquine Adherence During Pregnancy

Antonia Chan & Julia F. Simard, ScD  |  May 11, 2023

Hydroxychloroquine (HCQ) is nearly universally recommended for pregnant patients with systemic lupus erythematosus (SLE) to reduce lupus disease activity and adverse outcomes in pregnancy.1-3 Yet despite strong evidence supporting its benefits, HCQ appears underutilized, with several studies suggesting fewer than half of all women with lupus take this medication during pregnancy.4 How accurately these results…

2 AC&R Study Summaries: Racial Disparities in Lupus Trials & Post-Discharge Follow-Up in Lupus

Arthritis Care & Research  |  May 9, 2023

Racial Disparities in Lupus Clinical Trial Participation By Saira Z. Sheikh, MD Why was this study done? Lupus disproportionately affects Black and Latino populations, particularly women in childbearing years. Clinical trials of patients with lupus can advance the development of therapeutics and access to better treatments, as well as improve health outcomes for patients. However,…

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