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Allopurinol and Chronic Kidney Disease

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New Study: Does Urate-Lowering Therapy Reduce Gout-Patient Mortality?

The CKD-FIX trial randomized 369 adults with stage 3 or 4 chronic kidney disease (CKD), no history of gout and an increased risk of CKD progression to receive allopurinol, up to 300 mg daily, or placebo. To learn more, review our article or  take the quiz first.

In a new-patient consultation for joint pain, you see a 75-year-old man with a history of dementia, stage 3a chronic kidney disease (CKD) and nephrolithiasis. He has a uric acid level of 7.5 mg/dL. His medication list includes 300 mg daily allopurinol. Which would not be an indication for allopurinol?