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Biopsy for Lupus Nephritis

From the College  |  June 26, 2025

Renal biopsy showing class III lupus nephritis with rare foci of subendothelial deposits (wire loop lesions).

The ACR recently released a new guideline on the screening, treatment and overall management of lupus nephritis in children and adults. It specifically addresses when and how to use kidney biopsy in the diagnosis of lupus nephritis. These recommendations should not be used to limit or deny access to therapies because treatment decisions may vary due to the unique clinical situation and personal preferences of each individual patient.

According to the guideline, prompt percutaneous kidney biopsy should be performed to:

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