HLA-B*5801: Who Needs to Be Tested? From the College | July 22, 2024 HLA-B*5801 is an allele that confers an increased risk of allopurinol-induced reactions. The 2020 ACR Guideline for the Management of Gout  recommends initiating HLA genetic polymorphism testing in some populations before prescribing allopurinol, due to the higher prevalence of this gene in these populations. For more key points from the guideline, review our article, or take the quiz first. Which patient population should have HLA genetic polymorphism testing prior to starting allopurinol, according to the 2020 guideline? A. Laotian patients B. Thai patients C. Vietnamese patients D. Dutch patients None Time's up
