Materne et al. aimed to compare the risk of infection among patients with non-renal SLE using the injectable immunosuppressant belimumab vs. an oral immunosuppressant, azathioprine, mycophenolate or methotrexate.
Immunology Insights for the Rheumatologist
The ACR journal, Arthritis & Rheumatology has introduced a new educational series, with the complement system first in focus. “This isn’t simplified immunology for trainees,” says Dr. Bucala. “It’s for everyone.”
Glucocorticoid Use at Any Dose Increases Fracture Risk
The accepted wisdom is that the negative effects of glucocorticoids on bone depend on the dose and treatment duration. Adami et al. conducted this study to determine, in a real-life setting, the risk of fragility fracture associated with the dose of glucocorticoids in patients with inflammatory rheumatic musculoskeletal diseases.
Drinking Raises Risk of Hip Replacement Due to OA
Marchand et al. sought to examine the relationship between alcohol consumption and hip osteoarthritis (OA) in women. By analyzing data from the Nurses’ Health Study cohort in the U.S., the researchers concluded that an association may be observed between higher alcohol consumption and greater incidence of total hip replacement due to OA.
Treat to Target Lowers the Risk of Fracture in Patients with Gout
Using data from the U.K.’s Health Improvement Network, a primary care database, Wei et al. examined whether urate-lowering therapy (ULT) in a treat-to-target approach for patients with gout reduces the risk of fracture.
Tigulixostat Promising for Patients with Gout & Hyperuricemia
In a dose-finding, clinical trial, Terkeltaub et al. examined the safety and efficacy of tigulixostat, a nonpurine xanthine oxidase inhibitor, for lowering the serum urate levels of patients with gout and hyperuricemia.
Thick Skin & Solid Research: Necessary Ingredients for Publishing Success
Scientific publishing requires a commitment to clear writing, concise narratives and a willingness to accept feedback. Daniel Solomon, MD, editor-in-chief of Arthritis & Rheumatology, provides insights into his experiences.
RA Disease Activity & Alcohol Consumption Habits
Past studies have suggested that patients with rheumatoid arthritis (RA) who consume a moderate amount of alcohol may experience lower disease activity and higher quality of life than non-drinkers. In this study, Alfredsson, et al. confirmed earlier studies’ claims that alcohol consumption reduces disease activity in a dose-dependent manner, and also indicated that patients who stopped drinking post-baseline experienced worsened disease activity, more pain and a lower quality of life.
Platelets in the Pathogenesis of SLE
In a study, El Bannoudi et al. found that platelets contribute to the pathogenesis of SLE by secreting the proinflammatory platelet-associated lectin, galactoside-binding, soluble 3 binding protein (LGALS3BP), which also represents a novel biomarker of SLE clinical activity.
Anti-P. copri Antibody Responses in Patients with RA
Background & Objectives Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with immune responses to the patient’s own antigens and characterized by inflammation and substantial joint destruction. Prevotella copri, a gut commensal bacterium, has been reported to be an immune-relevant organism in individuals with RA. This study sought to evaluate antibody responses to anti-P….
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