Enthesitis is a central feature of spondyloarthritis (SpA). This review article summarizes the substantial progress that has been made in addressing the pathophysiology, molecular mechanisms, genetic associations, clinical features, diagnostic modalities and treatment of enthesitis. Further examination into the role of the inflammatory mediators, including IL-17, IL-22, and IL-23 as well as potentially others, in driving enthesitis and bone formation will be important to direct our attention toward future therapeutic targeted pathways in patients with SpA…
Authors Should Share Clinical Trial Data
NEW YORK (Reuters Health)—Authors should agree to share deidentified patient data as a condition for publication of a clinical trial report, according to a proposal from the International Committee of Medical Journal Editors (ICMJE). “Our patients generously and selflessly volunteer to participate in clinical trials on the promise that the knowledge gained will be used…
Rheumatology Researchers Explore Role of Neutrophils in Autoimmunity
SAN FRANCISCO—To unravel the mysteries of how autoimmunity begins in the body and, one day, to interrupt that process, rheumatology researchers are exploring the role of neutrophils, especially when they form and release neutrophil extracellular traps (NETs). At a panel discussion on Nov. 6, 2015, held at the American College of Rheumatology’s Basic Research Conference,…
Pattern Recognition Key to Fibrosing Lung Disease Diagnosis
SAN FRANCISCO—“Interstitial lung disease is the last bastion of great medicine,” according to Paul Noble, MD, chair, Department of Medicine, director, Women’s Guild Lung Institute, Vera and Paul Guerin Distinguished Chair in Pulmonary Medicine, Cedars-Sinai Medical Center, Los Angeles. Making it great medicine, he said, are the many things still unknown about this disease. In…
Search for Infectious Triggers of Rheumatic Disease Could Yield Options to Block Process
SAN FRANCISCO—Two hundred years ago, physicians knew nothing about what caused various forms of arthritis. Today, we have more clues about what may trigger rheumatic diseases, but still can’t pinpoint the culprits that set scores of inflammatory conditions in motion. Researchers discussed some of the background and recent findings that point to what immunologists call…
Rheumatic Disease Manifestations in the Central Nervous System
SAN FRANCISCO—Let’s say your radiologist comes to you and says that an angiogram gives a diagnosis of CNS vasculitis on four patients, all with acute onset of headache and stroke: One is a 25-year-old woman who is three months pregnant. Another is a 50-year-old man using excessive doses of nasal decongestants. Another is a 40-year-old…
Rheumatology Research Foundation’s Partnership with CRT Allows for Investment in Research, Training
The Rheumatology Research Foundation has infused more than $130 million into rheumatology research, education and training since it was established in 1985. The Foundation’s efforts have been greatly enhanced by the support of Corporate Roundtable (CRT) members. The CRT is a dynamic partnership between the Foundation and members of the pharmaceutical industry committed to furthering…
2015 ACR Guideline for the Treatment of Rheumatoid Arthritis
“Treat to target regardless of disease activity level” tops the list of recommendations for both early and established RA in the 2015 Guideline for the Treatment of Rheumatoid Arthritis. The guideline addresses six major topics, including DMARDs, glucocorticoids and biologics, and includes 74 recommendations. These recommendations are not prescriptive, and the treatment decisions should be made by physicians and patients together…
Rheumatology Research Foundation Expands Studies in Rheumatic Diseases Through Career Support
For the past 30 years, the Rheumatology Research Foundation has been an invaluable resource for investigators looking to further their careers and expand essential research into rheumatic diseases. Among the Foundation’s many award recipients is Robert Plenge, MD, PhD. In 2008, Dr. Plenge received a grant from the Foundation to pursue finding a genetic basis…
Dr. St.Clair Reflects on Progress in Rheumatology
As a practicing rheumatologist, I have experienced the increasing payer and government involvement shaping our evolving healthcare system. New payment models, changes in health insurance coverage, the federal mandate for the adoption of electronic health records and the implementation of ICD-10 are recent changes that have rocked our world. Our patients are also paying the…
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