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Systemic Lupus Erythematosus Resource Center

Systemic lupus erythematosus (SLE or lupus) is a chronic disease that causes systemic inflammation and affects multiple organs. Who is most at risk to develop SLE, and why? How does a person transition from healthy to active lupus? How can we help patients achieve and maintain remission? These are some of the questions explored in the articles below. Explore our collection of research reviews, case reports and clinical articles on advances in the diagnosis and management of SLE. Features are added often, so check back frequently.

Plus, dozens of research abstracts on various aspects of lupus were presented during ACR Convergence 2021, and David S. Pisetsky, MD, PhD, professor of medicine and immunology at Duke University School of Medicine in Durham, N.C., a staff rheumatologist at the Durham VA Medical Center and the very first physician editor of The Rheumatologist, highlights a few in the context of the work and their importance. (Also see his commentary from 2020.)

FEATURED ARTICLE: Difficult-to-Treat Lupus: When & How to Use New Therapies

ACR Convergence: Systemic Lupus Erythematosus

Research on SLE, pJIA & More Highlighted in 2nd ACR Convergence 2021 Plenary Session

Experts shined a spotlight on select abstracts of the latest rheumatology research, addressing such topics as racial disparities in the management of children with SLE, vitamin D or fish oil supplementation to prevent autoimmune disease & more.... [Read More]

Pediatric Rheumatology Year in Review: Basic Science

ACR Convergence 2021—The field of pediatric rheumatology has benefited from significant developments in the basic and translational sciences over the past year, and it can be challenging to keep up with the latest discoveries. In the Basic Science section of the Pediatric Rheumatology Year in Review at ACR Convergence, Tiphanie Vogel, MD, PhD, assistant professor… [Read More]

What Rheumatologists Should Know About Childhood-Onset SLE & Vasculitis

ACR CONVERGENCE 2021—Many of the effects of childhood-onset systemic lupus erythematosus (cSLE) and vasculitis carry into adulthood and present adult rheumatologists with key differences in managing these patients after their transition from a pediatric to an adult provider. “The young adult with childhood-onset lupus is similar in many ways to adults with lupus, but there… [Read More]

Lupus Update 2021: Classification Criteria, Disease Activity Measures & More

An SLE expert discusses the latest SLE stats, classification criteria, disease activity tracking, drugs & more.... [Read More]

Precision Medicine in Lupus

Targeted treatments for lupus still have a long way to go, but some studies are starting to pinpoint potential treatment pathways.... [Read More]

Experts Discuss Blood Disorders Commonly Seen in Lupus Patients

ACR CONVERGENCE 2021—Hematologic abnormalities are common in systemic lupus erythematosus (SLE), whether due to SLE itself or something else. As rheumatology professionals, we are routinely challenged by the management of cytopenias in our SLE patients. At the ACR’s annual meeting in 2021, two hematologists shared expert advice regarding common hematologic manifestations of SLE. Michael B…. [Read More]

The Great Debate: Belimumab vs. Voclosporin in Lupus Nephritis

ACR Convergence 2021—The Great Debate at the meeting sparked a thoughtful discussion on the future of lupus nephritis treatment strategies, with experts saying clinicians should be open to new ways of approaching patient care. In the past year, approvals of the monoclonal antibody belimumab and the calcineurin inhibitor voclosporin for use in lupus nephritis (when… [Read More]

How Pediatric Rheumatologists Are Moving Lupus Research Forward

In the 2021 Edmund L. Dubois, MD, Memorial Lectureship, Aimee Hersh, MD, discussed her work on defining research priorities in pediatric lupus.... [Read More]

Top 12: Research in Systemic Lupus Erythematosus at a Glance

Lupus often presents with a butterfly rash.

Dr. Pisetsky’s picks for the top research in lupus presented at ACR Convergence 2021.... [Read More]

Research, Case Reports & More

Clinical Challenges in SLE: Glucocorticoids—How Much Is too Much?

Glucocorticoids remain a prominent part of care for many patients with SLE but can have toxic side effects; this EULAR 2022 session discussed one institution’s approach to lower the dosage.... [Read More]

Difficult-to-Treat Lupus: When & How to Use New Therapies

Clinicians have numerous treatment options for SLE; in this EULAR 2022 session some of the newer therapies are reviewed.... [Read More]

Image Case Report: Refractory, Acute, Cutaneous Lupus

A 25-year-old Mexican American woman with a five-year history of systemic lupus erythematosus (SLE) presents with refractory, acute cutaneous lupus erythematosus (ACLE) and subacute cutaneous lupus erythematosus (SCLE) affecting the scalp, face and hands. Her serologic phenotype is characterized by elevated anti-nuclear, anti-double-stranded deoxyribonucleic acid (dsDNA), anti-ribonucleoprotein (RNP), anti-Smith and anti-SS-A (Ro) antibodies and chronically… [Read More]

Improving Lupus Drug Regimen Adherence Among Minorities

Rheumatologists can do better at helping systemic lupus erythematosus patients from racial and ethnic minority groups adhere to their lupus medication regimens, according to a paper published in Arthritis Care & Research. Researchers from Duke University examined medication adherence barriers from the perspectives of healthcare providers and patients. Their findings suggest more attention should be… [Read More]

Case Report: Drug-Induced Lupus

The incidence of drug-induced lupus continues to rise as clinicians expand their therapeutic armamentarium. An estimated 15,000–30,000 cases of drug-induced lupus occur every year in the U.S. alone.1 It is a well-known, but rare, complication of commonly used medications, such as anti-hypertensive, anti-arrhythmic and anti-epileptic drugs, as well as biologic and immune checkpoint therapies.2,3 The… [Read More]

Updates in Pediatric Lupus: Experts Discuss Advances in Lupus Nephritis Treatments, Monogenic Lupus & More

PRSYM—At the 2021 Pediatric Rheumatology Symposium (PRSYM), a session on lupus provided a robust discussion of recent advances in lupus treatments and genetic discoveries in pediatric rheumatology. Lupus Nephritis The first speaker was Shaun Jackson, MD, PhD, a pediatric nephrologist and rheumatologist and associate professor at Seattle Children’s. His presentation focused on state-of-the-art treatments in… [Read More]

2-Year Extension Study Supports Voclosporin to Treat Patients with Lupus Nephritis

Research has shown voclosporin in combination with MMF and low-dose steroids benefits patients with lupus nephritis, significantly increasing the speed of remission. New data from an ongoing extension study demonstrate a positive risk/benefit profile.... [Read More]

Rare Disease Sheds Light on the Origins of Lupus

Patients with the rare DNASE1L3 biallelic null mutation present with childhood-onset disease that resembles lupus. This observation prompted research into how abnormalities in the enzyme DNASE1L3 are associated with lupus, with researchers finding autoantibody-mediated impairment of DNASE1L3 activity may be a common non-genetic mechanism leads to anti-dsDNA autoreactivity in SLE.... [Read More]

New Insights into CD8+ T Cells & Lupus

A recent study demonstrated that exposure to type I interferon contributes to the pathogenesis of SLE via the metabolic rewiring of CD8+ T cells, which promotes cell death.... [Read More]

Platelets: An Underrecognized Piece of the Lupus Puzzle

Platelets may be a key source of mitochondrial antigens in systemic lupus erythematosus, according to a recent study.... [Read More]

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Rheumatology Research Foundation

The Foundation is the largest private funding source for rheumatology research and training in the U.S.

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The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

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ISSN 1931-3268 (print)
ISSN 1931-3209 (online)