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Food for Thought: On Eating & Inflammation in Rheumatic Disease

Susan Bernstein  |  November 14, 2020

Think Beyond the Prescription Pad

Neha Shah, MD

Nearly one-third of patients with RA in a recent survey were dissatisfied with their treatment plan, and in another survey of adults with self-reported, doctor-diagnosed arthritis, almost 40% said they had sought out a complementary or alternative therapy for their symptoms.17,18 “So our patients are seeking care outside of the rheumatologist’s office. We can move in the direction of more patient-centered care by using complementary medicine,” said rheumatologist Neha S. Shah, MD, assistant professor of medicine at Stanford University in California.

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Rheumatologists may help patients build self-efficacy (i.e., the perception that they can do something to cope with their disease) by talking with them about lifestyle habits, such as nutrition, exercise, tobacco use, sleep or stress, and help them set goals to improve these habits.

“This lifestyle-medicine approach is one way we can empower our patients and allow them to put some control back into their lives,” said Dr. Shah. “To be an integrative rheumatologist, one need not do an 800-hour acupuncture course or get a master’s in nutrition or become a certified yoga instructor. What it really takes is asking the right questions” and carefully listening to patients’ answers, she said.

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For patients who ask about herbal treatments, Dr. Shah discussed the potentially positive effects of two Ayurvedic herbs (turmeric and ginger) on rheumatic disease patients, who may easily incorporate these spices into their daily diet or take them as supplements. Turmeric, also called curcumin, improved knee osteoarthritis pain in a 2019 double-blind, randomized, placebo-controlled trial.19 Ginger supplementation improved some immunity and inflammation gene expression in patients with active RA in a 2019 trial.20

Rheumatologists may feel they have little time to cover these topics during busy clinic hours, so Dr. Shah suggests virtual meetings with groups of patients interested in complementary medicine.

“This ideal of perfect health may not be attainable for our patients who are in advanced stages of autoimmune disease, but helping them get one step closer to their optimal state of well-being is certainly within our power,” she said.


Susan Bernstein is a freelance journalist based in Atlanta.

References

  1. Brandhorst S, Choi IY, Wei M, et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan. Cell Metabol. 2015 Jul 7;22(1):86–89.
  2. Choi IY, Piccio L, Childress P, et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep. 2016 Jun 7;15(10):2136–2146.
  3. Rangan P, Choi IY, Wei M, et al. Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology. Cell Rep. 2019 Mar;26(10):2704–2719.e6.
  4. Tedeschi SK, Costenbader KH. Is there a role for diet in the therapy of rheumatoid arthritis? Curr Rheumatol Rep. 2016 May;18(5):23.
  5. Gan RW, Demoruelle MK, Deane KD, et al. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Ann Rheum Dis. 2017 Jan;76(1):147–152.
  6. Di Guiseppe D, Crippa A, Orsini N, et al. Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis. Arthritis Res Ther. 2014;16(5):446.
  7. Lu B, Solomon DH, Costenbader KH, et al. Alcohol consumption and risk of incident rheumatoid arthritis in women: A prospective study. Arthritis Rheumatol. 2014 Aug;66(8):1998–2005.
  8. Barbhaiya M, Lu B, Sparks JA, et al. Influence of alcohol consumption on the risk of systemic lupus erythematosus among women in the Nurses’ Health Study cohorts. Arthritis Care Res. 2017 Mar;69(3):384–392.
  9. Hu Y, Costenbader KH, Gao X, et al. Sugar-sweetened soda consumption the risk of developing rheumatoid arthritis in women. Amer J Clin Nutr. 2014 Sep;100(3):959–967.
  10. Sparks JA, Barbhaiya M, Tedeschi SK, et al. Inflammatory diet pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol. 2019 Jan;38(1):243–250.
  11. Hu Y, Costenbader KH, Gao X, et al. Mediterranean diet and rheumatoid arthritis incidence in women. Arthritis Care Res. 2015 May;67(5):597–606.
  12. Tedeschi SK, Barbhaiya M, Sparks JA, et al. Dietary patterns and risk of systemic lupus erythematosus in women. Lupus. 2020 Jan;29(1):67–73.
  13. Proudman SM, James MJ, Spargo LD, et al. Fish oil in recent-onset rheumatoid arthritis: A randomised, double-blind controlled trial within algorithm-based drug use. Ann Rheum Dis. 2015 Jan;74(1):89–95.
  14. Wright SA, O’Prey FM, McHenry MT, et al. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis. 2008 Jun;67(6):841–848.
  15. Hagen KB, Byfuglien MG, Falzon L, et al. Dietary interventions for rheumatoid arthritis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006400.
  16. Skoldstam L, Hagfors L, Johansson G. An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis. 2003 Mar;62(3):208–214.
  17. O’Neill K, Crowson C, Symons D, et al. Importance of discussing RA treatment goals: Patients report providers seldom discuss treatment goals and outcomes improve when goals are discussed [abstract]. Arthritis Rheumatol. 2019;71(suppl 10).
  18. Zhang Y, Dennis JA, Bishop FL, et al. Complementary and alternative medicine use by U.S. adults with self‐reported doctor‐diagnosed arthritis: Results from the 2012 National Health Interview Survey. PM R. 2019 Oct;11(10):1059–1069.
  19. Henrotin Y, Malaise M, Wittoek R, et al. Bio-optimized curcuma longa extract is efficient on knee osteoarthritis pain: A double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther. 2019 Jul 27;21(1):179.
  20. Aryaeian N, Shahram F, Mahmoudi M, et al. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active rheumatoid arthritis. Gene. 2019 May 25;698:179–185.

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