Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

  • Conditions
    • Axial Spondyloarthritis
    • Gout and Crystalline Arthritis
    • Myositis
    • Osteoarthritis and Bone Disorders
    • Pain Syndromes
    • Pediatric Conditions
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Sjögren’s Disease
    • Systemic Lupus Erythematosus
    • Systemic Sclerosis
    • Vasculitis
    • Other Rheumatic Conditions
  • FocusRheum
    • ANCA-Associated Vasculitis
    • Axial Spondyloarthritis
    • Gout
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Systemic Lupus Erythematosus
  • Guidance
    • Clinical Criteria/Guidelines
    • Ethics
    • Legal Updates
    • Legislation & Advocacy
    • Meeting Reports
      • ACR Convergence
      • Other ACR meetings
      • EULAR/Other
    • Research Rheum
  • Drug Updates
    • Analgesics
    • Biologics/DMARDs
  • Practice Support
    • Billing/Coding
    • EMRs
    • Facility
    • Insurance
    • QA/QI
    • Technology
    • Workforce
  • Opinion
    • Patient Perspective
    • Profiles
    • Rheuminations
      • Video
    • Speak Out Rheum
  • Career
    • ACR ExamRheum
    • Awards
    • Career Development
  • ACR
    • ACR Home
    • ACR Convergence
    • ACR Guidelines
    • Journals
      • ACR Open Rheumatology
      • Arthritis & Rheumatology
      • Arthritis Care & Research
    • From the College
    • Events/CME
    • President’s Perspective
  • Search

A 46-Year Study Traces the Lupus Death Rate from 1968–2013

Kurt Ullman  |  Issue: September 2018  |  September 20, 2018

GTbov / shutterstock.com

GTbov / shutterstock.com

A study published in Annals of Internal Medicine in December 2017 looked at trends in lupus mortality over a 46-year period. The researchers say they set out to close some knowledge gaps.

“There [was] a knowledge gap relating to the large differences we see in death rates from one study to another, which could have been due to different methodologies used in different studies,” says Ram R. Singh, MD, professor of medicine and pathology at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and the study’s senior author. “Most of these studies were done in rheumatology centers and didn’t capture the death rates in the general population. There were no studies covering the entire U.S.”

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

“To overcome these limitations, we utilized mortality data from the Centers for Disease Control and Prevention’s National Vital Statistics System, encompassing more than 99% of all deaths in the 50 states and District of Columbia from the years 1968 through 2013,” says lead author Eric Y. Yen, MD, a clinical instructor at the UCLA Department of Medicine.

More than 68,000 deaths from systemic lupus erythematosus (SLE) and 100,851,288 non-SLE deaths were reported during that period. The researchers used JointPoint trend analysis of annual age-standardized mortality rates (ASMR) for both disease- and non-disease-related causes by sex, race/ethnicity and geographic region.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

“The number of deaths reported in this study is large,” says Dr. Singh. “There were more than 50,000 reports where SLE was the underlying cause of death, according to the death certificate, and another 18,000 where SLE was a contributing or secondary cause of death. Using 46 years of data, this was a large study of long duration.”

Death Rate Comparisons

Dr. Singh (left) and Dr. Yen (right)

Dr. Singh (left) and Dr. Yen (right)

During the period of interest, five- and 10-year survival rates for SLE improved from less than 50% during the 1950s to around 90% in the 1980s. But the SLE ASMR decreased less than the non-SLE ASMR, with a 34.6% increase in the ratio of SLE to non-SLE ASMR. The ASMR for the general population went down every year, while SLE ASMR decreased between 1968 and 1975, increased between 1975 and 1999 and then decreased again for the rest of the study period.

Among those dying from other causes, the death rate dropped by 44% from 1968–2013. In contrast, in lupus it dropped only 24% over the same period.

Page: 1 2 3 | Single Page
Share: 

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:death ratelower death ratesmortality rate

Related Articles

    Lupus Survival Is Improving Slowly

    October 30, 2017

    NEW YORK (Reuters Health)—Systemic lupus erythematosus (SLE) mortality has declined during the past 46 years in the U.S.—but more slowly than mortality in the general population, according to a nationwide study. “Based on our experience in the clinic and according to previous reports showing improvement in the short-term (five- to 10-year) survival in lupus, I…

    Study Reveals Lupus Is a Leading Cause of Death in U.S. Women

    October 18, 2018

    Systemic lupus erythematosus (SLE) is a leading cause of death among young women, according to an August 2018 study in Arthritis & Rheumatology.1 To help determine where SLE ranks among causes of death, Eric Y. Yen, MD, and Ram Raj Singh, MD, conducted a population-based study using nationwide mortality counts for all female residents of…

    Studies Highlight Risk of Damage from Lupus Treatments

    April 20, 2017

    WASHINGTON, D.C.—Conference goers who braved the final day of the 2016 ACR/ARHP Annual Meeting were awarded for their stamina by learning about issues relating to the damage caused by systemic lupus erythematosus (SLE) during the session Systemic Lupus Erythematosus—Clinical Aspects and Treatment V: Damage and Morbidity. Minimizing Damage: Early Use of GC-Sparing Strategies Jayne Little,…

    A Better Family Plan

    October 1, 2007

    How to minimize the risks of pregnancy for women with SLE

  • About Us
  • Meet the Editors
  • Issue Archives
  • Contribute
  • Advertise
  • Contact Us
  • Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 1931-3268 (print). ISSN 1931-3209 (online).
  • DEI Statement
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences