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A Case of Lupus Podocytopathy

Vineetha Philip, MD, MPH, Myriam Guevara, MD, Angelina Edwards, MD, & Ziad M. El-Zaatari, MD  |  June 17, 2024


Vineetha Philip, MD, MPH, is a second-year fellow in the adult rheumatology program at Houston Methodist Hospital.

Myriam Guevara, MD, is the program director for the adult rheumatology fellowship program at Houston Methodist Hospital.

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Angelina Edwards, MD, is the program director for the nephrology fellowship program at Houston Methodist Hospital.

Ziad M. El-Zataari, MD, is an assistant professor of clinical pathology and laboratory medicine at Houston Methodist Hospital and practices as an academic surgical pathologist with expertise in medical renal pathology.

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References

  1. Chen D, Hu W. Lupus podocytopathy: A distinct entity of lupus nephritis. J Nephrol. 2018 Oct;31(5):629–634.
  2. Hu W, Chen Y, Wang S, et al. Clinical-morphological features and outcomes of lupus podocytopathy. Clin J Am Soc Nephrol. 2016 Apr;11(4):585–592.
  3. Oliva-Damaso N, Payan J, Oliva-Damaso E, et al. Lupus podocytopathy: An overview. Adv Chronic Kidney Dis. 2019 Sep;26(5):369–375.
  4. Dube GK, Markowitz GS, Radhakrishnan J, et al. Minimal change disease in systemic lupus erythematosus. Clin Nephrol. 2002 Feb;57(2):120–126.
  5. Hertig A, Droz D, Lesavre P, et al. SLE and idiopathic nephrotic syndrome: Coincidence or not? Am J Kidney Dis. 2002 Dec;40(6):1179–1184.
  6. Han TS, Schwartz MM, Lewis EJ. Association of glomerular podocytopathy and nephrotic proteinuria in mesangial lupus nephritis. Lupus. 2006;15(2):71–75.
  7. Almaani S, Meara A, Rovin BH. Update on lupus nephritis. Clin J Am Soc Nephrol. 2017;12(5):825–835.
  8. Bomback AS, Markowitz GS. Lupus podocytopathy: A distinct entity. Clin J Am Soc Nephrol. 2016 Apr;11(4):547–548.
  9. Yu F, Haas M, Glassock R, et al. Redefining lupus nephritis: Clinical implications of pathophysiologic subtypes. Nat Rev Nephrol. 2017 Aug;13(8):483–495.
  10. Trivedi S, Zeier M, Reiser J. Role of podocytes in lupus nephritis. Nephrol Dial Transplant. 2009 Dec;24(12):3607–3612.
  11. Navarro D, Ferreira AC, Viana H, et al. Morphological indexes: Can they predict lupus nephritis outcomes? A retrospective study. Acta Med Port. 2019 Oct;32(10):635–640.
  12. Rovin BH, Adler SG, Barratt J, et al. Executive summary of the KDIGO 2021 guideline for the management of glomerular diseases. Kidney Int. 2021 Oct;100(4):753–779.
  13. Bomback AS. Nonproliferative forms of lupus nephritis: An overview. Rheum Dis Clin North Am. 2018 Nov;44(4):561–569.
  14. Wang Y, Yu F, Song D, et al. Podocyte involvement in lupus nephritis based on the 2003 ISN/RPS system: A large cohort study from a single centre. Rheumatology (Oxford). 2014;53(7): 1235–1244.
  15. Jeruschke S, Alex D, Hoyer PF, Weber S. Protective effects of rituximab on puromycin-induced apoptosis, loss of adhesion and cytoskeletal alterations in human podocytes. Sci Rep. 2022 Jul; 12(1):12297.
  16. Wang SF, Chen YH, Chen DQ, et al. Mesangial proliferative lupus nephritis with podocytopathy: A special entity of lupus nephritis. Lupus. 2018 Feb; 27(2):303–311.

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Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:case reportLupus nephritisPodocytopathySLE Resource Center

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