Explore this issueSeptember 2013
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The ACR is excited by the fantastic lineup of investigators from a variety of disciplines who are a part of the ACR Basic Research Conference and Clinical Research Conference on Friday, October 25, and Saturday, October 26, in San Diego, before the 2013 ACR/ARHP Annual Meeting.
Beyond Germline Genetics: New Perspectives on Rheumatic Disease Predisposition
The Basic Research Conference will focus on understanding how susceptibility for rheumatic diseases can arise from alterations in gene expression or cellular phenotype, due to mechanisms other than variations in the underlying germline DNA sequence. These presentations will embrace evolving concepts of epigenetics and the range of associated molecular mechanisms. The emphasis will be on the development of rheumatic diseases, such as rheumatoid arthritis, lupus, vasculitis, osteoarthritis, and spondylarthropathies, and how these inherited changes affect cartilage, bone, and periarticular tissues, as well as disease-characteristic innate and adaptive immune abnormalities. Underlying principles and evidence demonstrating the inheritance of susceptibility by factors outside of the genetic encoding sequences will be discussed, along with the molecular factors and regulatory organizing factors responsible for these epigenetic pathways. Speakers will address disease states that arise separately from the influence of genetic independent variants, and will ask attendees to consider why genetically identical individuals may display differences in phenotype and disease discordance.