Monosodium urate (MSU) crystal deposition commonly occurs within the distal appendicular skeleton. The peripheral nature of gout is a hallmark feature described in the ACR and the European League Against Rheumatism (EULAR) clinical practice guidelines.1
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Explore This IssueJune 2019
In this article, we report a rare presentation of a common disease: a case of axial gouty arthropathy masquerading as infectious discitis.
Our patient is a 66-year-old man with longstanding, untreated hyperuricemia, chronic kidney disease and poorly controlled diabetes abruptly transitioned from colchicine to allopurinol due to the cost of colchicine. Approximately 72 hours after the switch, he presented at a local emergency department with fever, confusion and severe low back pain.
Unenhanced magnetic resonance imaging of his lumbar spine revealed diffuse T2 hyperintensity, concerning for L4–L5 discitis. His clinical presentation confusion, fever, atrial fibrillation with rapid ventricular response and tachypnea—and laboratory evidence of leukopenia and elevated inflammatory markers were concerning for sepsis from a spinal source. He was treated in accordance with the institutional sepsis bundle and transferred to our tertiary care center.
Biopsy of the suspicious lesion within the L4–L5 intervertebral disc space showed purulent material without organism; however, the pathologist noted abundant monosodium urate (MSU) crystals. Blood cultures prior to antibiotics and subsequent disc cultures were negative. A definitive diagnosis of acute axial gout was established. Consultation with a rheumatologist confirmed a polyarticular peripheral gouty attack in the left shoulder, elbow and wrist.
Due to this patient’s heavy disease burden and difficult-to-control hyperglycemia with intravenous glucocorticoids, he was initially treated with three intravenous doses of anakinra and slowly tapered to a maintenance dose of methylprednisolone with colchicine while titrating allopurinol to achieve a uric acid goal of less than 5.0 mg/dL.
Our patient silently suffered from chronic hyperuricemia, which resulted in a heavy disease burden. MSU deposits formed tophi within the intervertebral disc of the lumbar spine.
Gout is characterized by the ACR/EULAR as “at least one episode of swelling, pain or tenderness in a peripheral joint or bursa.”2 Note the word peripheral. It is commonly felt that axial involvement is rare.3 Only 133 cases of spinal gout were reported from 1950–2015.4 Many suspect this phenomenon is more prevalent than commonly appreciated due to its under-reported nature.5
The gold standard for diagnosis of gouty arthropathy is microscopic evidence of MSU crystals from the joint aspirate. Dual-energy computer tomography (DECT) is helpful in cases in which the diagnosis through biopsy is inconclusive due to the small concentration of MSU crystals usually seen early on in the disease.6 During the acute phase of the disease, joint aspirations may not demonstrate MSU crystals 25% of the time.7 Joint space inaccessibility or aspiration contraindications may make a noninvasive modality the preferred choice for an examination.6,8
DECT offers the advantage of estimating the urate crystal volume load, which helps in monitoring the treatment outcome.9 It also helps differentiate between other forms of crystalline arthropathy.6 Ultrasound imaging can detect urate crystal deposits within cartilage and within the joint fluid, described as the double contour sign and starry sky, respectively.10 DECT and ultrasound have similar sensitivity for detecting gouty arthritis; however, the rate of false-negative cases was higher with DECT.10
Our patient did not undergo a DECT due to lack of availability, but had ultrasound-guided peripheral joint aspiration. A computed tomography of the spine showed facet involvement with end plate erosions, surrounded by sclerosis and calcifications. The sclerosis indicates a more chronic process, and the facet joints are typically not affected in infectious discitis or osteomyelitis. These radiological findings, along with negative blood cultures, MSU crystals in aspirate, peripheral joint involvement and poor response to antibiotics, helped differentiate spinal gout from infectious discitis.
Consider spinal gout in the differential diagnosis of patients with chronic kidney disease, a gout history and tophi presenting with acute back pain.
Jessita Albert Messiah Dhas, MD, is a resident in the Department of Internal Medicine at Geisinger Medical Center, Danville, Pa.
Erik O’Connell, DO, is rheumatology fellow in the Department of Rheumatology at Geisinger Medical Center, Danville, Pa.
Lisa Schroeder, MD, is an attending physician in the Department of Rheumatology at Geisinger Medical Center, Danville, Pa.
- Khanna D, Khanna PP, Fitzgerald JD, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and anti-inflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken). 2012 Oct;64(10):1447–1461.
- Khanna D, Fitzgerald JD, Khanna PP, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct;64(10):1431–1446.
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- Omoumi P, Verdun FR, Guggenberger R, et al. Dual-energy CT: Basic principles, technical approaches, and applications in musculoskeletal imaging (part 2). Semin Musculoskelet Radiol. 2015 Dec;19(5):438–445.
- Swan A, Amer H, Dieppe P. The value of synovial fluid assays in the diagnosis of joint disease: A literature survey. Ann Rheum Dis. 2002 Jun;61(6):493–498.
- Dalbeth N. Dual-energy computed tomography: Molecular imaging for gout. The Rheumatologist. 2014 Jun;8(6):40–41.
- Choi HK, Al-Arfaj AM, Eftekhari A, et al. Dual energy computed tomography in tophaceous gout. Ann Rheum Dis. 2009 Oct;68(10):1609–1612.
- Gruber M, Bodner G, Rath E, et al. Dual-energy computed tomography compared with ultrasound in the diagnosis of gout. Rheumatology (Oxford). 2014 Jan;53(1):173–179.