Apolipoprotein E Polymorphism Associated with Hyperuricemia in Chinese Population

The authors also found that, in particular, male patients with hyperuricemia were more likely to have the APOE-ε2ε3 genotype and APOE-ε2 allele than were male controls. This was true for both Han and Hui subjects. Moreover, the levels of TG, LDL-C, and UA were significantly different among the APOE genotype groups ε2ε3, ε3ε3 and ε3ε4 for both normouricemic and hyperuricemic patients.

The authors acknowledge that although the APOE-ε2ε3 genotype and APOE-ε2 allele are associated with serum UA levels, it is still not clear how APOE polymorphism may contribute to UA metabolism. (posted 12/12/14)

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

1. Wu J, Qiu L, Guo XZ, et al. Apolipoprotein e gene polymorphisms are associated with primary hyperuricemia in a Chinese population. 2014. PLoS One. Oct 30;9(10):e110864.