ACR Convergence 2025| Video: Rheum for Everyone, Episode 26—Ableism

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As Understanding of Long COVID Deepens, the Search for Therapies Continues

Thomas R. Collins  |  November 7, 2025

“When we talk about viral persistence, presumably there’s more than just the antigen. But it’s possible that it plays a role; we just don’t fully understand or know about that as of yet,” Dr. Geng responded. “What I try to emphasize also is the huge amount of data, including meta-analyses, that have shown the benefit of vaccines, not just for acute COVID, but for long COVID as well, in terms of prevention.”


Thomas Collins is a freelance medical writer based in Florida.

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References

  1. Ryu JK, Yan Z, Montano M, et al. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature. 2024 Sep;633(8031):905–913.
  2. Kantor AB, Akassoglou K, Stavenhagen JB. Fibrin-targeting immunotherapy for dementia. J Prev Alzheimers Dis. 2023;10(4):647–660.
  3. Geng LN, Bonilla H, Hedlin H, et al. Nirmatrelvir-ritonavir and symptoms in adults with postacute sequelae of SARS-CoV-2 infection: The STOP-PASC randomized clinical trial. JAMA Intern Med. 2024 Sep 1;184(9):1024–1034.
  4. Monje M, Iwasaki A. The neurobiology of long COVID. Neuron. 2022 Nov 2;110(21):3484–3496.

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