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Case Report: Amyloid Beta-Related Angiitis of the Central Nervous System

Alexandros Grivas, MD, Nikil Revuri, MD, Aleksandra Karaseva, MD, Basimah AlBalooshy, MD, & Andres M. Ponce, MD  |  Issue: October 2024  |  October 8, 2024


Alexandros Grivas, MD, is a resident in the division of internal medicine at Thomas Jefferson University Hospital, Philadelphia.

Nikil Revuri, MD, is a rheumatologist at Thomas Jefferson University Hospital, Philadelphia. Aleksandra Karaseva, MD, is a resident in the division of pathology at Thomas Jefferson University Hospital, Philadelphia.

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Basimah AlBalooshy, MD, is a radiologist at Thomas Jefferson University Hospital, Philadelphia.

Andres M. Ponce, MD, is a rheumatologist at Thomas Jefferson University Hospital, Philadelphia.

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References

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  2. Chwalisz BK. Cerebral amyloid angiopathy and related inflammatory disorders. J Neurol Sci. 2021 May:424:117425.
  3. Cho TA, Jones A. CNS vasculopathies: Challenging mimickers of primary angiitis of the central nervous system. Best Pract Res Clin Rheumatol. 2020 Aug;34(4):101569.
  4. Evangelatos G, Grivas A, Pappa M, et al. Cranial giant cell arteritis mimickers: A masquerade to unveil. Autoimmun Rev. 2022 May;21(5):103083.
  5. de Souza A, Tasker K. Inflammatory cerebral amyloid angiopathy: A broad clinical spectrum. J Clinical Neurol. 2023 May;19(3):230–241.
  6. Chwalisz BK. Cerebral amyloid angiopathy and related inflammatory disorders. J Neurol Sci. 2021 May:424:117425.
  7. Salvarani C, Hunder GG, Morris JM, et al. Aβ-related angiitis: Comparison with CAA without inflammation and primary CNS vasculitis. Neurology. 2013 Oct 29;81(18):1596–1603.
  8. Chu S, Xu F, Su Y, et al. Cerebral amyloid angiopathy (CAA)-related inflammation: Comparison of inflammatory CAA and amyloid-β-related angiitis. J Alzheimers Dis. 2016;51(2):525–532.
  9. Auriel E, Charidimou A, Gurol ME, et al. Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation. JAMA Neurol. 2016 Feb;73(2):197–202.
  10. Storti B, Gabriel MM, Sennfält S, et al. Rare forms of cerebral amyloid angiopathy: Pathogenesis, biological and clinical features of CAA-ri and iCAA. Front Neurosci. 2023 Jul:17:1219025.
  11. Tabaee Damavandi P, Storti B, Fabin N, et al. Epilepsy in cerebral amyloid angiopathy: An observational retrospective study of a large population. Epilepsia. 2023 Feb;64(2):500–510.
  12. Malhotra K, Theodorou A, Katsanos AH, et al. Prevalence of clinical and neuroimaging markers in cerebral amyloid angiopathy: A systematic review and meta-analysis. Stroke. 2022 Jun;53(6):1944–1953.
  13. Eng JA, Frosch MP, Choi K, et al. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol. 2004 Feb;55(2):250–256.
  14. Salvarani C, Morris JM, Gianni C, et al. Imaging findings of cerebral amyloid angiopathy, aβ-related angiitis (ABRA), and cerebral amyloid angiopathy–related inflammation. Medicine (Baltimore). 2016 May;95(20):e3613.
  15. Danve A, Grafe M, Deodhar A. Amyloid beta-related angiitis—A case report and comprehensive review of literature of 94 cases. Semin Arthritis Rheum. 2014 Aug;44(1):86–92.
  16. Salvarani C, Brown Jr RD, Calamia KT, et al. Primary central nervous system vasculitis: Comparison of patients with and without cerebral amyloid angiopathy. Rheumatology (Oxford). 2008 Nov;47(11):1671–1677.
  17. Corovic A, Kelly S, Markus HS. Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome. Int J Stroke. 2018 Apr;13(3):257–267.
  18. Aghetti A, Sène D, Polivka M, et al. Cerebral amyloid angiopathy related inflammation with prominent meningeal involvement. A report of 2 cases. Front Neurol. 2019 Sep:10:984.
  19. Chung KK, Anderson NE, Hutchinson D, et al. Cerebral amyloid angiopathy related inflammation: Three case reports and a review. J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):20–26.
  20. Li D, Qin W, Guo Y, et al. Clinical, laboratory, and radiological features of cerebral amyloid angiopathy-related inflammation (CAA-ri): Retrospective, observational experience of a single centre. Neurol Sci. 2023 Feb;44(2):631–638.
  21. Theodorou A, Palaiodimou L, Malhotra K, et al. Clinical, neuroimaging, and genetic markers in cerebral amyloid angiopathy-related inflammation: A systematic review and metaanalysis. Stroke. 2023 Jan;54(1):178–188.
  22. Ronsin S, Deiana G, Geraldo AF, et al. Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation. Neurology. 2016 Mar;86(10):912–919.
  23. Auriel E, Charidimou A, Gurol ME, et al. Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation. JAMA Neurol. 2016 Feb;73(2):197–202.
  24. Castro Caldas A, Silva C, Albuquerque L, et al. Cerebral amyloid angiopathy associated with inflammation: Report of 3 cases and systematic review. J Stroke Cerebrovasc Dis. 2015 Sep;24(9):2039–2048.
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Filed under:ConditionsOther Rheumatic ConditionsVasculitis Tagged with:amyloid β-related angiitiscase reportcentral nervous system vasculitiscerebral amyloid angiopathy

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