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Case Report: Cardiac Complications in Scleroderma

Sophia C. Weinmann, MD, & Richard D. Brasington Jr., MD, FACP  |  Issue: April 2018  |  April 26, 2018

In conclusion, the next time an SSc patient reports palpitations during a review of systems, remember that it could be more than just a feeling.


Sophia C. Weinmann, MDSophia C. Weinmann, MD, recently completed a rheumatology fellowship at Washington University in St. Louis. She is now a medical instructor at Duke University, Durham, N.C.

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Richard Brasington, MDRichard D. Brasington Jr., MD, FACP, is a professor of medicine and the rheumatology fellowship program director at Washington University in St. Louis. He is the recipient of multiple teaching awards that recognize his dedication to rheumatology.

References

  1. Lambova S. Cardiac manifestations in systemic sclerosis. World J Cardiol. 2014 Sep 26;6(9):993–1005.
  2. Kahan A, Coghlan G, McLaughlin V. Cardiac complications of systemic sclerosis. Rheumatology (Oxford). 2009 Jun;48(Suppl 3):
  3. 45–48.
  4. Rockey DC, Bell PD, Hill JA. Fibrosis—A common pathway to organ injury and failure. N Engl J Med. 2015 Mar 19;372(12):1138–1149.
  5. De Jong S, Van Veen TAB, Van Rijen HVM, De Bakker JMT. Fibrosis and cardiac arrhythmias. J Cardiovasc Pharmacol. 2011 Jun;57(6):630–638.
  6. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009 Jun;119(6):1420–1428.
  7. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003 Dec;112(12):1776–1784.
  8. Van Rooij E, Olson EN. Searching for MiR‑acles in cardiac fibrosis. Circ Res. 2009 Jan 30;104(2):138–140.
  9. Champion HC. The heart in scleroderma. Rheum Dis Clin North Am. 2008 Feb; 34(1):181–190.
  10. Wong TC, Piehler K, Meier CG, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012 Sep 4;126(10):1206–1216.

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Filed under:Systemic Sclerosis Tagged with:arrhythmiacase reportpulmonary fibrosisScleroderma

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