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Case Report: Hajdu-Cheney Syndrome

Ibtissam Gad, MD, Firas Askar, MD, Sudhaker Rao, MD, & Ayad Alhatib, MD  |  Issue: October 2023  |  October 11, 2023

This case highlights the importance of a thorough differential and evaluation in a patient presenting with a rare finding. Moreover, limited treatments are currently available for HCS, which necessitates ruling out treatable diseases.


Ibtissam Gad, MD (@igadmd), completed her internal medicine residency at University Hospitals/Case Western, Cleveland, and her rheumatology fellowship at Henry Ford Health, Detroit. She has a major interest in medical education and is heavily involved in the ACR’s Fellows in Training Subcommittee. She created RheumDoodles.

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Firas Askar, MD, is a first-year rheumatology fellow at Henry Ford Health. He is highly interested in rare manifestations of autoimmune and musculoskeletal diseases.

Sudhaker Rao, MD, obtained his medical degree from Osmania University, Hyderabad India, and completed an internal medicine residency at Booth Memorial Hospital, New York, before joining Henry Ford Hospital as a fellow in endocrinology. He has been section head of the Bone and Mineral Division and program director for the Endocrinology Fellowship Program. He has contributed extensively to the field of bone and mineral disorders, including authoring or coauthoring more than 300 peer-reviewed papers, abstracts and book chapters.

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Ayad Alkhatib, MD, has been a senior staff rheumatologist at Henry Ford Health since 2017. He completed a rheumatology fellowship at UT Southwestern Medical Center, Dallas. He is also the director of the psoriatic arthritis and psoriasis clinic at Henry Ford Health and involved in the rheumatology fellowship program.

References

  1. Canalis E, Zanotti S. Hajdu-Cheney syndrome: A review. Orphanet J Rare Dis. 2014 Dec;9:200.
  2. Botou A, Bangeas A, Alexiou I, et al. Acro-osteolysis. Clin Rheumatol. 2017 Jan; 36(1):9–14.
  3. Bocci EB, Biscontini D, Olivieri I, et al. Acro-osteolysis of the big toe in a patient with psoriatic arthritis. J Rheumatol. 2009 Sep;36(9):2044.
  4. Limenis E, Stimec J, Kannu P, et al. Lost bones: Differential diagnosis of acro-osteolysis seen by the pediatric rheumatologist. Pediatr Rheumatol Online J. 2021 Jul 14;19(1):113.
  5. Niamane R, Bezza A, El Hassani S, et al. Value of the radiographic criteria “fingers and toes” in the early diagnosis of psoriatic arthritis. J Radiol. 2005 Mar;86(3):321–324.
  6. Siao-Pin S, Damian LO, Muntean LM, et al. Acro-osteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis. Exp Ther Med. 2016 Nov;12(5):3459–3463.

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Filed under:ConditionsOsteoarthritis and Bone DisordersOther Rheumatic Conditions Tagged with:acro-osteolysiscase reportHajdu-Cheney syndrome

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