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Case Review: Lupus Patient with Acute Disseminating Encephalomyelitis

Teresa Sosenko, MD, Anca Musetescu, MD, PhD, Neha Gandhi, MD, Scott Friedstrom, MD, & Diana Girnita, MD, PhD  |  Issue: January 2018  |  January 19, 2018

Patients often respond favorably to steroids. In addition, doctors should initiate cyclophosphamide for neurologic manifestations of lupus.

Final Thoughts

Acute disseminated encephalomyelitis as a symptom of SLE remains a rare, but unquestionably severe, neuropsychiatric symptom of SLE. Outcomes for ADEM vary widely, mostly depending on its severity. Fortunately, in the case presented here, the team made a diagnosis in a timely manner, and the patient responded well to treatment.

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Today, the patient is back to his normal self and ready to restart his job.


Teresa Sosenko, MDTeresa Sosenko, MD, is an internal medicine resident at Trihealth Good Samaritan Hospital in Cincinnati, Ohio, with an interest in rheumatology.

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Anca Emanuela Musetescu, MD, PhDAnca Emanuela Musetescu, MD, PhD, is a lecturer in rheumatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania.

Neha Gandhi, MDNeha Gandhi, MD, is the associate program director for the Internal Medicine Residency at Trihealth Good Samaritan Hospital in Cincinnati, and a primary care physician.

Scott Friedstrom, MDScott Friedstrom, MD, is the Internal Medicine Residency Program Director at Trihealth Good Samaritan Hospital in Cincinnati, and an infectious disease specialist.

Diana Girnita, MD, PhDDiana Girnita, MD, PhD, is a rheumatologist and faculty for internal medicine at Trihealth Good Samaritan Hospital in Cincinnati.

References

  1. Kim JM, Son CN, Chang HW, et al. Simultaneous presentation of acute disseminated encephalomyelitis (ADEM) and systemic lupus erythematosus (SLE) after enteroviral infection: Can ADEM present as the first manifestation of SLE? Lupus. 2015 May;24(6): 633–637.
  2. Bermejo PE, Ruiz A, Beistegui M, et al. Hemorrhagic acute disseminated encephalomyelitis as first manifestation of systemic lupus erythematosus. J Neurol. 2008 Aug;255(8):1256–1258.
  3. Klippel JH, Stone JH, Crofford LJ, et al. (2008) Primer on the Rheumatic Disease. New York, New York: Springer.
  4. Firestein GS, Budd RC, Gabriel SE, et al. (2013) Kelley’s Textbook of Rheumatology. Philadelphia, Pa.: Elsevier Saunders.
  5. Hochberg MC, Silman AJ, Smolen JS, et al. (2011) Rheumatology. Philadelphia, Pa: Mosby Elsevier.
  6. Rahmlow MR, Kantarci O. Fulminant demyelinating diseases. Neurohospitalist. 2013 Apr;3(2):81–91.
  7. Wang PN, Fuh JL, Liu HC, et al. Acute disseminated encephalomyelitis in middle-aged or elderly patients. Eur Neurol. 1996;36(4):219–223.
  8. Marin SE, Callen DJ. The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: An update post application of the 2007 consensus criteria. Neuroimaging Clin N Am. 2013 May;23(2):245–266.
  9. Zettl UK, Stuve O, Patejdl R. Immune-mediated CNS diseases: A review on nosological classification and clinical features. Autoimmun Rev. 2012 Jan;11(3):167–173.
  10. de Seze J, Debouverie M, Zephir H, et al. Acute fulminant demyelinating disease: A descriptive study of 60 patients. Arch Neurol. 2007 Oct;64(10):1426–1432.
  11. Alexander M, Murthy JM. Acute disseminated encephalomyelitis: Treatment guidelines. Ann Indian Acad Neurol. 2011 Jul;14(Suppl 1);S60–S64.
  12. Honkaniemi J, Dastidar P, Kahara V, et al. Delayed MR imaging changes in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol. 2001 Jun–Jul;22(6):1117–1124.
  13. Borras-Novell C, García Rey E, Perez Baena LF, et al. Therapeutic plasma exchange in acute disseminated encephalomyelitis in children. J Clin Apher. 2015 Dec;30(6):335–339.
  14. Likasitwattanakul S, Chiewvit P. Acute disseminated encephalomyelitis in Siriraj Hospital: Clinical manifestations and short-term outcome. J Med Assoc Thai. 2012 Mar;95(3):391–396.

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