Other Rheumatic Conditions
Less is known about the implications of other rheumatologic conditions, such as vasculitis, scleroderma and myositis, on pregnancy, but it is clear is that certain medications must be avoided during the gestational period. These include methotrexate, leflunomide, mycophenolate mofetil, cyclophosphamide and non-steroidal anti-inflammatory drugs after the second trimester when the potential of premature closure of the ductus arteriosus exists.
You Might Also Like
Explore This IssueNovember 2018
To conclude her talk, Dr. Bermas stressed that close communication with women with rheumatologic conditions before, during and after pregnancy is key to ensuring the health of baby and mother, and by continuing to build partnerships between obstetricians and rheumatologists, the children can indeed be our future.
Anat Chemerinski is a third-year resident in obstetrics and gynecology at the University of Pennsylvania. She earned her MD from the University of Maryland School of Medicine.
Jason Liebowitz is a second-year fellow in rheumatology at Johns Hopkins University. He earned his MD from Johns Hopkins University School of Medicine and completed his residency at Johns Hopkins Bayview.
- Clara DM, Luca P, Rita GM, et al. Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: Influence of the disease severity and therapy on the ovarian reserve. Endocrine. 2018 Oct 15.
- de Man YA, Dolhain RJ, van de Geijn FE, et al. Disease activity of rheumatoid arthritis during pregnancy: Results from a nationwide prospective study. Arthritis Rheum. 2008 Sep 15;59(9):1241–1248.
- Chakravarty EF, Nelson L, Krishnan E. Obstetric hospitalizations in the United States for women with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 2006 Mar;54(3):899–907.
- Bermas BL, Kim SC, Huybrechts K, et al. Trends in use of hydroxychloroquine during pregnancy in systemic lupus erythematosus patients from 2001 to 2015. Lupus. 2018 Jan 1:961203317749046.
- Fischer-Betz R, Specker C. Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome. Best Pract Res Clin Rheumatol. 2017 Jun;31(3):397–414.
- Lightstone L, Hladunewich MA. Lupus nephritis and pregnancy: Concerns and management. Semin Nephrol. 2017 Jul;37(4):347–353.