Cryoglobulins: Quantified & Characterized

Obtained with the use of modern assays, the findings from this very large collection of cryoglobulins provide an update on cryoglobulin distribution and characteristics, with minimal selection bias. Despite strict pre-analytical conditions, a negative finding for the presence of cryoglobulin must be confirmed in a second sample. RF activity and complement decreases were rarely detected.

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Excerpted and adapted from:

Kolopp-Sarda MN, Nombel A, Miossec P. Cryoglobulins today: Detection and immunologic characteristics of 1,600 positive samples from 13,000 patients obtained over six years. Arthritis Rheumatol. 2019 Nov;71(11):1904–1912.

A study that focused on the detection and immunological characteristics of cryoglobulins provides insights for rheumatologists and other rheumatology providers, as well as lab professionals. Co-researchers Marie N. Kolopp-Sarda, PharmD, PhD, and Pierre Miossec, MD, PhD, Clinical Immunology Unit, Department of Immunology and Rheumatology, University of Lyon, France, included in their retrospective study, published in…

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