The Rheumatologist
COVID-19 News
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Ankylosing Spondylitis Resource Center
    • Gout Resource Center
    • Psoriatic Arthritis Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
    • Workforce
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Systemic Lupus Erythematosus Resource Center
      • Rheumatoid Arthritis Resource Center
      • Gout Resource Center
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / EULAR 2013: Research Hints at Risk Factors for Rheumatoid Arthritis

EULAR 2013: Research Hints at Risk Factors for Rheumatoid Arthritis

September 1, 2013 • By Thomas R. Collins

  • Tweet
  • Email
Print-Friendly Version / Save PDF

You Might Also Like
  • Rheumatoid Arthritis Research Provides New Insights on Risk Factors, Identification Tools, Intervention
  • Genetic Risk Factors for Rheumatoid Arthritis Merit More Research
  • 2013 ACR/ARHP Annual Meeting: Genetic Research Yields Clues to Pathogenesis of Rheumatoid Arthritis, Psoriatic Arthritis
Explore This Issue
September 2013
Also By This Author
  • Progress Slow in Development of Useful Biomarkers for Rheumatoid Arthritis Treatment
Complex Analyses Hint at RA Roots
Some research indicates that the roots of RA may be found in the lung.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

MADRID—Prevention is the ultimate goal with any disease, including rheumatoid arthritis (RA), and researchers here at the European League Against Rheumatism (EULAR) 2013 Annual European Congress of Rheumatology, held June 12–15, presented cutting-edge work aimed at that end, with projects from identifying who is most at risk to potential ways to intervene and prevent onset.

Prevention as a bona fide topic in itself represents progress, although Dirkjan van Schaardenburg, MD, PhD—who chaired the session and is professor of rheumatology at Jan van Breemen Research Institute in Amsterdam—said answering these questions will require a lot more work. “There are many more answers to be found for the questions,” he said.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Which Antibodies Indicate Risk?

Solbritt Rantapaa Dahlqvist, MD, PhD, professor of rheumatology at the University of Umeå in Sweden, presented work that delves deeper into the relationship between antibodies against citrullinated proteins and peptides (ACPA) and the development of RA.

She and her team mined data from the Medical Biobank of Northern Sweden, a collection of more than 210,000 blood samples from 131,000 people in the general population, who give blood samples in exchange for a medical check-up.

Researchers analyzed the samples from those with nonsymptomatic pre-RA, those with RA, and controls to assess the presence of antibodies against an array of citrullinated peptides.

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

They found that the fluorescence intensity of antibodies against fibrinogen (Fib) ß36-52, Fibß74, CEP-1, citC1III, and filaggrin were significantly increased in those with predisease compared to controls. Antibodies against Fibß36-52, CEP-1, and filaggrin increased gradually, eventually reaching the highest levels of all antibodies before the onset of symptoms.

The earliest detectable antibodies—Fib∝591 and vimentin 60–75—increased only slightly before the onset of symptoms, but more so after disease onset.

The risk for development of RA was highest for filaggrin (odds ratio [OR] 11.64), Fibß74 (OR 10.68), and CEP-1 (OR 6.27), and those risks remained high after adjustment for the presence of HLA-shared epitope and smoking, suggesting an independent relationship for RA development, Dr. Dahlqvist said.

Researchers also looked at the risk involved with combinations of antibodies, HLA-shared epitope, and smoking and found that the combinations including CEP-1 or Fibß36-52 came with an OR of 38.8 for developing RA, compared to having either one individually and being HLA-shared epitope negative and nonsmoker.

Dr. Dahlqvist and her team have also evaluated the role of salt intake. The work is unpublished so far, but she said the findings have been interesting.

Pages: 1 2 3 | Single Page

Filed Under: Conditions, Meeting Reports, Rheumatoid Arthritis Tagged With: anti-CCP antibodies, citrullinated targets, EULAR 2013, Research, Rheumatoid arthritisIssue: September 2013

You Might Also Like:
  • Rheumatoid Arthritis Research Provides New Insights on Risk Factors, Identification Tools, Intervention
  • Genetic Risk Factors for Rheumatoid Arthritis Merit More Research
  • 2013 ACR/ARHP Annual Meeting: Genetic Research Yields Clues to Pathogenesis of Rheumatoid Arthritis, Psoriatic Arthritis
  • Bronchial Tissue Immune Activation Seen in Early Rheumatoid Arthritis

Rheumatology Research Foundation

The Foundation is the largest private funding source for rheumatology research and training in the U.S.

Learn more »

Meeting Abstracts

Browse and search abstracts from the ACR Convergence and ACR/ARP Annual Meetings going back to 2012.

Visit the Abstracts site »

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2021 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.