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Hepatitis Reaction with Rituximab Sparks Drug Safety Alert

M.J. Burton, MD, K.L. Winthrop, MD, MSPH, & J.W. Baddley, MD, MPH  |  Issue: January 2015  |  January 1, 2015

References

  1. Winthrop KL, Calabrese LH. Let the fog be lifted: Screening for hepatitis B virus before biological therapy. Ann Rheum Dis. 2011 Oct;70(10):1701–1703.
  2. Perez-Alvarez R, Diaz-Lagares C, Garcia-Hernandez F, et al. Hepatitis B virus (HBV) reactivation in patients receiving tumor necrosis factor (TNF)-targeted therapy: Analysis of 257 cases. Medicine (Baltimore). 2011 Nov;90(6):359–371.
  3. Petrarca A, Rigacci L, Caini P, et al. Safety and efficacy of rituximab in patients with hepatitis C virus-related mixed cryoglobulinemia and severe liver disease. Blood. 2010 Jul 22;116(3):335–342.
  4. Ferri C, Ferraccioli G, Ferrari D, et al. Safety of anti-tumor necrosis factor-alpha therapy in patients with rheumatoid arthritis and chronic hepatitis C virus infection. J Rheumatol. 2008 Oct;35(10):1944–1949.

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Filed under:Biologics/DMARDsDrug Updates Tagged with:drugFDAhepatitisrheumatologyrituximabSafetyvirus

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