Ibuprofen More Likely to Raise BP than Naproxen or Celecoxib

“It’s good to know that people who have arthritis and pain syndromes have a choice of the medications they might take,” he says. “It’s possible that people who are older or who are at risk of GI bleeding probably should start out with Celebrex, because it’s less likely to cause hypertension and it’s less likely to cause cardiovascular events than the other two drugs.”

References

1. Ruschitzka F, Borer JS, Krum H, et al. Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial. European Heart Journal. 2017 Aug 28. ehx508.
2. Nissen SE, Yeomans ND, Solomon DH, et al. Cardiovascular safety of celecoxib, naproxen or ibuprofen for arthritis. N Engl J Med. 2016 Dec 29:2519–2529. doi: 10.1056/NEJMoa1611593.