Obesity is a worldwide health issue and a major and modifiable risk factor for many patients with knee osteoarthritis (OA). For overweight and obese adults, the National Institutes of Health (NIH) recommend patients set an initial goal of losing 10% of their baseline weight. However, the benefits beyond what has been shown with 10% weight loss in patients with knee OA are unknown.
In their latest research, Stephen P. Messier, PhD, Wake Forest University, Winston-Salem, N.C., and colleagues conducted a secondary analysis of the weight loss groups in the Intensive Diet and Exercise for Arthritis (IDEA) trial. The goal of the analysis was to determine the effect of greater weight loss on the clinical and mechanistic outcomes at the 18-month follow up.
The 240 study participants were overweight and obese adults over 55 years old with pain and radiographic knee OA. Participants were assigned to one of four groups according to weight loss achieved: less than 5%, 5–10%, 10–20% and more than 20%. The results of the study were published in the November 2018 issue of Arthritis Care & Research.