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You are here: Home / Articles / Letters: More Tools for Inflammatory Myopathies

Letters: More Tools for Inflammatory Myopathies

February 1, 2014 • By Stephan Regenass, MD

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Dear Dr. Jones and Dr. Wortmann:
Thank you for the informative article, and for your comments on autoantibodies as diagnostic tools in inflammatory myopathies. On this issue, I would like to comment that several markers that are useful and already or soon commercially available as test kits are not mentioned in the article yet (e.g., anti–HMGCoA-Reductase, TIF1-gamma, MDA-5, TRIM21/Ro52kD, PM-Scl).

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February 2014

Secondly, I was surprised about the statement, “Similarly, anti–mitochondrial M2 antibodies (anti-Mi-2) are generally, though not always, associated with a very good prognosis.” Could it be that it was intended to comment on Anti-Mi2? Anti-Mi2 as part of the nucleosome remodelling and histon deacetylating complex (NuRD) is a relatively specific marker of dermatomyositis, which is unrelated to antimitochondrial antibodies. In the diagnostic lab, we often encounter requests for “M2” instead of “Mi2” and vice-versa, and it is easy to see why—it might have happened in this article as well.

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Stephan Regenass, MD
Clinic of Immunology
University Hospital of Zuerich

The Editors Respond

Dr. Regenass is correct that “anti–mitochondrial M2 antibodies” should have been printed as “anti-Mi2 antibodies.” The Rheumatologist apologizes for this typographical error.

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Filed Under: Conditions, Systemic Inflammatory Syndromes Tagged With: diagnostic tool, inflammatory myopathy, Letters, patient care, rheumatologist, rheumatologyIssue: February 2014

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