To investigate, Dr. van Daalen and colleagues assessed malignancy rates in AAV patients treated between 2000 and 2014, including 119 who received only cyclophosphamide, 41 who received only rituximab, 114 who received both and 48 who received neither.
As reported in Annals of the Rheumatic Diseases, online on Nov. 29, 33 patients developed a total 45 malignancies during an average followup of 5.6 years. This represented a 1.89-fold increased malignancy risk overall, for AAV patients compared to the general population.
The risk increase was not significant if non-melanoma skin cancer was excluded from the analyses (standardized incidence ratios, 1.09). The risk of non-melanoma skin cancer alone was increased 4.58-fold overall.
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