These trends persisted after adjusting for age, sex, BMI, smoking status, comorbidities and other potential confounders across the subcohorts. They observed a similar improved mortality rate among African American, Hispanic and white patients.
Finally, they observed a 44% lower risk of cardiovascular deaths and 63% lower risk of infection-related deaths during the study period, contributing to the declining overall mortality trend.
This improved survival among patients with ESRD due to LN may be explained by a combination of improvements in the management of ESRD and of underlying SLE.
Conclusion: In the more recent years of the period 1995–2014, there was a considerable reduction in all-cause mortality among white, African American and Hispanic patients, with reduced risk of death from CVD and infection. Collectively, these trends provide an important benchmark of improving care in this high-risk population.
Excerpted and adapted from:
Jorge A, Wallace ZS, Zhang Y, et al. All-cause and cause-specific mortality trends of end-stage renal disease due to lupus nephritis from 1995 to 2014. Arthritis Rheumatol. 2019 March;71(3):403–410.
