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New Study Probes Hydroxychloroquine Adherence During Pregnancy

Antonia Chan & Julia F. Simard, ScD  |  Issue: May 2023  |  May 11, 2023


Antonia Chan is a fourth-year medical student at Stanford University School of Medicine, Calif., and an incoming internal medicine resident physician at Beth Israel Deaconess Medical Center, Boston. She is interested in rheumatology/immunology, shared decision making and health services research.

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Julia F. Simard, ScD, is an associate professor in the Department of Epidemiology and Population Health, Division of Immunology & Rheumatology in the Department of Medicine and, by courtesy, in the Department of Obstetrics and Gynecology at Stanford University School of Medicine. She is interested in misclassification bias, pregnancy outcomes in people with rheumatic disease,and epidemiologic methods.

References

  1. Sperber K, Hom C, Chao CP, et al. Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases. Pediatr Rheumatol Online J. 2009 May 13;7:9.
  2. Clowse MEB, Magder L, Witter F, et al. Hydroxychloroquine in lupus pregnancy. Arthritis Rheum. 2006 Nov;54(11):3640–3647.
  3. Costedoat-Chalumeau N, Amoura Z, Duhaut P, et al. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: A study of one hundred thirty-three cases compared with a control group. Arthritis Rheum. 2003 Nov;48(11):3207–3211.
  4. Liu LH, Fevrier HB, Goldfien R, et al. Understanding nonadherence with hydroxychloroquine therapy in systemic lupus erythematosus. J Rheumatol. 2019 Oct;46(10):1309–1315.
  5. Simard JF, Liu EF, Chakravarty E, et al. Reconciling between medication orders and medication fills for lupus in pregnancy. ACR Open Rheumatol. 2022 Dec;4(12):1021–1026.
  6. Chan A, Hirz A, Chaichian Y, et al. Exploring reasons for non-use of hydroxychloroquine in SLE pregnancy. Arthritis Rheumatol. 2022; 74 (suppl 9).
  7. Jiang M, Chang Y, Wang Y, et al. Highrisk factors for adverse pregnancy outcomes in systemic lupus erythaematosus: A retrospective study of a Chinese population. BMJ Open. 2021 Nov 16;11(11):e049807.
  8. Bermas BL, Kim SC, Huybrechts K, et al. Trends in use of hydroxychloroquine during pregnancy in systemic lupus erythematosus patients from 2001 to 2015. Lupus. 2018 May;27(6):1012–1017.
  9. Dollinger J, Brasil C, Wong M, et al. Patient preferences for hydroxychloroquine in systemic lupus (SLE). Arthritis Rheumatol. 2021; 73 (suppl 9).
  10. Maheswaranathan M, McKenna K, Corneli A, et al. Patient perspective of helpfulness of lupus medications: A qualitative study of medication use within the Type 1 and 2 SLE model. Arthritis Rheumatol. 2020; 72 (suppl 10).
  11. Barr AC, Clowse M, Maheswaranathan M, et al. Association of hurried communication and low patient self-efficacy with persistent nonadherence to lupus medications. Arthritis Care Res. 2023 Jan;75(1):69–75.
  12. Leung J, Baker EA, Kim AHJ. Exploring intentional medication non-adherence in patients with systemic lupus erythematosus: The role of physician-patient interactions. Rheumatol Adv Pract. 2021 Jan 24; 5(1):rkaa078.
  13. Clowse MEB, Eudy AM, Revels J, et al. Provider perceptions on the management of lupus during pregnancy: barriers to improved care. Lupus. 2019 Jan;28(1):86–93.
  14. Sun K, Corneli AL, Dombeck C, et al. Barriers to taking medications for systemic lupus erythematosus: A qualitative study of racial minority patients, lupus providers, and clinic staff. Arthritis Care Res. 2022 Sep;74(9):1459–1467.

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Filed under:ConditionsResearch RheumSystemic Lupus Erythematosus Tagged with:adherenceHydroxychloroquine (HCQ)pregnancy

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