“Our results suggest that lifestyle changes—smoking cessation in men and weight reduction in women—as well as optimizing methotrexate use may facilitate rapid reduction of inflammation, an essential goal of treatment in early RA,” she writes in a press release.
Dr. Bartlett and her colleagues compared predictors of persistent low, moderate and high disease activity in 1,628 men and women in the first year of treatment for early RA. Participants were enrolled in the Canadian Early Arthritis Cohort (CATCH) from 2007 to 2016 and were receiving guideline-based care. Overall, 72% were female, the average age was 55, the average number of comorbidities was two and the average symptom duration as six months.
Participants had active disease at baseline and were followed-up for at least 12 months. They underwent clinical assessments, questionnaires, and lab tests.