NEW YORK (Reuters Health)—Patients with rheumatoid arthritis (RA) have alterations in their oral and gut microbiomes that partially normalize with treatment, according to results from a metagenome-wide association study.
The microbiota influence metabolic and immune homeostasis, and microbial triggers have been postulated in RA, but little is known about the oral and gut microbiomes of RA patients.
Dr. Xuan Zhang, from Peking Union Medical College, Beijing, China, and colleagues compared the gut microbiomes of 77 treatment-naïve RA patients and 80 unrelated healthy controls, 17 treatment-naive RA patients paired with 17 healthy relatives, and 21 samples from DMARD-treated RA patients. They compared oral microbiomes from treatment-naive RA patients (54 oral, 51 saliva) and healthy controls (51 dental, 47 saliva).
The oral and gut microbiomes of individuals with RA were distinct from those of healthy individuals, according to the July 27 Nature Medicine online report.