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FDA Approves AbbVie’s New Rheumatoid Arthritis Drug

Reuters Staff  |  August 19, 2019

(Reuters)—The U.S. Food and Drug Administration (FDA) on Friday approved AbbVie Inc.’s new treatment for rheumatoid arthritis (RA), a win for the drugmaker seeking to widen its portfolio as its blockbuster flagship therapy Humira (adalimumab)‎‎ faces competition. The drug, Rinvoq (upadacitinib), is a JAK inhibitor. It is set to compete with Pfizer Inc.’s Xeljanz (tofacitinib)…

Otilimab Begins Phase 3 Clinical Studies for RA

Michele B. Kaufman, PharmD, BCGP  |  August 19, 2019

In a four-part clinical trial program, researchers are assessing the safety and efficacy of otilimab with placebo in RA patients, along side conventional treatments, such as tofacitinib, and DMARDs…

The Association of Rheumatology Professionals Names Grant Recipients

From the College  |  August 16, 2019

It is with great pleasure that the ARP congratulates the 2019 recipients of the Mentored Nurse Practitioner/Physician Assistant Award for Workforce Expansion. The purpose of the NP/PA Award is to increase the supply of rheumatology healthcare providers to better meet the needs of people with rheumatic diseases across the U.S., particularly in geographically underserved areas….

The Choose Rheumatology Experience Encourages Med Students, Residents to Pursue Rheumatology Careers

From the College  |  August 16, 2019

Medical students and residents are choosing careers in rheumatology, thanks in part to the annual Choose Rheumatology Experience hosted by the Rheumatology Research Foundation during the ACR/ARP Annual Meeting. The Choose Rheumatology Experience is a special half-day program designed to help future physicians and rheumatology professionals navigate the Annual Meeting. Cultivating interest in rheumatology is…

Dr. Gary Firestein: Musician & Semi-Retired Surfer

Carol Patton  |  August 16, 2019

Roughly 20 years ago, Gary S. Firestein, MD, was surfing at Cloudbreak, a sheltered reef nearly three miles south of Namotu Island in Fiji. With waves soaring as high as 20 feet, it’s either a surfer’s dream or nightmare, and ranked among the 10 most challenging waves anywhere on the planet. At the time, Dr….

Recent Awards & Appointments in Rheumatology

Gretchen Henkel  |  August 16, 2019

Prestigious Carol Nachman Prize for Research in Rheumatology Awarded to Ellen Gravallese On May 10, Ellen M. Gravallese, MD, the Myles J. McDonough Chair in Rheumatology and chief of the Division of Rheumatology at University of Massachusetts Medical School, Worcester, was awarded the prestigious Carol Nachman Prize for lifetime achievement in rheumatology research in Wiesbaden,…

In Mouse Model, a TLR-9 Deficiency May Trigger Severe Lupus

Kurt Ullman  |  August 16, 2019

Toll-like receptors play an important role in host defense. TLR-7 recognizes viral ssRNA, but also plays a role in the development of systemic lupus erythematosus (SLE). Genetic ablation of a similar receptor, TLR-9, results in opposite effects, with severe disease and kidney involvement. The mechanism of how this works remains unknown. Anna-Marie Fairhurst, PhD, from…

Study Probes Whether Belimumab Can Lower Vasculitis Relapse Rate

Catherine Kolonko  |  August 16, 2019

In an international clinical trial, adding the drug belimumab to standard maintenance therapy for patients in remission with vasculitis did not lower the relapse rate. The double-blind, placebo-controlled study evaluated the safety and efficacy of belimumab as adjunctive therapy to maintain remission in anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Results of the multi-center, industry-sponsored…

Case Report: Not All Crystals Are Gout

Katherine Yates, MD, Erin H. Penn, MD, & Minna J. Kohler, MD   |  August 16, 2019

Patients with chronic kidney disease (CKD) often experience joint pain due to various etiologies, including crystalline arthropathies, renal osteodystrophy, amyloid arthropathy, erosive osteoarthritis, avascular necrosis and even erosive spondylarthrosis.1 Below, we present a case of crystalline arthropathy in a patient with chronic kidney disease, mistaken for gout. The Case A 29-year-old man was admitted to…

Case Report: RA Patient Suffers Methotrexate-Induced Cutaneous Lesions

Nitasha Kumar, MD  |  August 16, 2019

Methotrexate (MTX) remains the predominant medication used by rheumatologists to treat rheumatoid arthritis (RA). Doses of 7.5–25 mg per week with daily folic acid are generally prescribed. Despite its common use, MTX must be prescribed cautiously given the potential adverse effects when taken incorrectly or without folic acid supplementation. Cases of MTX-induced cutaneous ulceration have…

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