Patients with Active RA Have Higher Drug Efflux Transporter Activity

Because the study included analysis of peripheral lymphocytes as a whole, the investigators were unable to determine whether specific cell populations might be responsible for the drug-resistant phenotype. However, they did note that the fact that the increased transporter activity was found in the peripheral blood and not the synovia, suggests that an alteration in peripheral blood may be contributing to RA pathology.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

Atisha-Fregoso Y, Lima G, Pascual-Ramos V, et al. Rheumatoid arthritis disease activity is determinant for ABCB1 and ABCG2 drug-efflux transporters function. PLoS One. 2016 Jul 21;11(7):e0159556. doi: 10.1371/journal.pone.0159556. eCollection 2016.

Pegloticase is a new alternative therapy for patients with severe, refractory gout unresponsive to other urate-lowering agents. The goal of this therapy is to reduce disease burden, tophi size and frequency of flares and to improve quality of life when other treatments have failed. Persistent lowering of plasma uric acid (PUA) to less than 6…

CHICAGO—The Gout and Hyperuricemia scientific session at the 2018 ACR/ARHP Annual Meeting opened with a talk by Tony R. Merriman, PhD, a research professor at the University of Otago, New Zealand. His talk focused on molecular epidemiology, with an emphasis on the interactions between genes and environmental exposures, and their contributions to gout. Dr. Merriman…

ACR Convergence 2020—In May 2020, the ACR published its updated guideline for the management of gout.1 It followed on the heels of a 2017 gout guideline published by the American College of Physicians.2 Although the guidelines provide similar recommendations on the treatment of acute gout, they differ importantly in the use of uric acid-lowering therapy…

Gout is the most common type of inflammatory arthritis in adults, and it typically occurs in men over the age of 50. When gout presents in younger patients or in women, this should warrant consideration of secondary causes. We describe an unusual genetic cause of tophaceous gout in a young, premenopausal woman. Case Report In…

Treatment Options for Severe Refractory Gout When Pegloticase Fails

Research Is Advancing Our Understanding of Gout & Hyperuricemia

Optimize Gout Management with the Latest Evidence-Based Guidance

Case Report: Does a Young Woman with Gitelman Syndrome Have Gout?

Related Articles